2010 Fiscal Year Final Research Report
Molecular basis of hyperthermia-thorough investigation into a newly identified heat-shock induced protein
| Project/Area Number |
20590708
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
NAKAJIMA Hideo Kanazawa Medical University, 医学部, 准教授 (00333394)
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| Co-Investigator(Kenkyū-buntansha) |
MOTOO Yoshiharu 金沢医科大学, 医学部, 教授 (80210095)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 代替医療 |
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| Research Abstract |
Family with sequence similarity 107 (FAM107) consists of two subtypes of FAM107A and B in mammals. Emerging data regarding FAM107A as a candidate tumor suppressor gene have been accumulated, although few biological information is available about the other FAM107 family protein, FAM107B. We have reported that FAM107B expression was downregulated in cancer and induced by heat-shock stimulation, and designated it as heat shock-inducible tumor small protein (HITS). Since forced expression of HITS inhibited tumor growth, HITS would be a potential tumor suppressor gene, which contrasts with previously described oncogenic activities of other heat shock proteins.
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