2010 Fiscal Year Final Research Report
A study of environmental and hereditary determinants for thinness and eating abnormalities in women.
| Project/Area Number |
20590714
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
ANDO Tetsuya National Center of Neurology and Psychiatry, 精神保健研究所心身医学研究部, 室長 (50311428)
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| Research Collaborator |
KOMAKI Gen 独立行政法人国立精神・神経医療研究センター, 精神保健研究所心身医学研究部, 部長 (70225564)
ICHIMARU Yuhei 東京家政大学, 家政学部・栄養学科, 教授
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| Project Period (FY) |
2008 – 2010
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| Keywords | 若年女性 / ダイエット / やせ / 摂食障害 / 体格指数 / 体組成 / 遺伝子 / ストレスコーピング |
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| Research Abstract |
Associations between anthropometry, eating behaviors, psychological and somatic characteristics were investigated in young women. Thinness was related to irregular menstruation. Dieting was related to higher current and past body mass index. Binge eating was correlated with higher depression, anxiety, obsession, perfectionism, and lower self-esteem. Stressor and coping influenced eating attitudes. Genetic polymorphisms of beta 3 adrenaline receptor, uncoupling protein-1, and beta2adrenaline receptor were not associated with any anthropometric measures.A polymorphism in ghrelin gene was associated with higher body mass index and fat mass. Brain derived neurotrophic factor polymorphism was related to lower height, weight and lean mass.
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[Journal Article] Genetic Research Group for Eating Disorders. A ghrelin gene variant may predict crossover rate from restricting type anorexia nervosa to other phenotypes of eating disorders : a retrospective survival analysis.2010
Author(s)
Ando T, Komaki G, Nishimura H, Naruo T, Okabe K, Kawai K, Takii M, Oka T, Kodama N, Nakamoto C, Ishikawa T, Suzuki-Hottab M, Minatozaki K, Yamaguchi C, Nishizono-Maher A, Kono M, Kajiwara S, Suematsu H, Tomita Y, Ebana S, Okamoto Y, Nagata K, Nakai Y, Koide M, Kobayashi N, Kurokawa N, Nagata T, Kiriike N, Takenaka Y, Nagamine K, Ookuma K, Murata S
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Journal Title
Psychiatric Genetics 20
Pages: 153-159
Peer Reviewed
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[Journal Article] Japanese Genetic Research Group for Eating Disorders (JGRED), Shirasawa S. Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers.2009
Author(s)
Nakabayashi K, Komaki G, Tajima A, Ando T, Ishikawa M, Nomoto J, Hata K, Oka A, Inoko H, Sasazuki T
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Journal Title
J Hum Genet 54
Pages: 531-537
Peer Reviewed
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[Journal Article] 町田英世日本人の摂食障害姉妹発症例における生涯病型,代償行動,ならびに体重の関連性の有無について2009
Author(s)
後藤直子,小牧元,安藤哲也,伊澤敏,石川俊男,大隈和喜,岡部憲二郎,黒川順夫,小西貴幸,高宮静男,武井美智子,傳田健三,冨田和巳,長井信篤,長峯清秀,西園マーハ文,本間一正,
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Journal Title
Peer Reviewed
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