Identification of novel genes related with stem cell and cancer stem cell in the transdifferentiation to gastric intestinal mataplasia.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590716
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: IMATANI Akira Tohoku University, 病院, 講師 (30333876)
• Project Period (FY): 2008 – 2010
• Keywords: 胃 / 分化制御 / 幹細胞 / 癌

Research Abstract

The transdifferentiation to intestinal metaplasia is considered as a gastric carcinogenesis sequence in H.pylori infection. Down-regulation of a homeobox gene Sox2 might contribute to the gastric carcinogenesis in this manner. We established an in vitro model of this transdifferentiation by down-regulation of Sox2, and identified a pseudokinase gene Tribbles using Microarray analyses. This gene overexpressed in the human gastric cancer tissues and cell lines.

Research Products

• [Presentation] H.pylori感染胃粘膜におけるHMGボックス遺伝子Sox2発現抑制による腸上皮化生進展の機序 (2010)
  • Author(s): 今谷晃、阿曽沼祥、浅野直喜、近藤穣、千葉隆士、伏谷淳、下瀬川徹
  • Organizer: 第9回消化器病フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2010-11-20
• [Presentation] Downregulation of embryonic stem cell-related gene Sox2 induced transdifferentiation to intestinal etaplasia in Helicobacter pylori infected gastric mucosa (2010)
  • Author(s): Yutaka Kondo, Akira Imatani, Sho Asonuma, Hidetomo Konishi, Takashi Chiba, Naoki Asano, Kaname Uno, Yasuhiko Abe, Katsunori Iijima, Tomoyuki Koike, Tooru Shimosegawa
  • Organizer: 第1回 International Topic Conference(日本消化器病学会)
  • Place of Presentation: 鎌倉
  • Year and Date: 2010-09-25