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2010 Fiscal Year Final Research Report

Development of genomics-based prophylaxis strategy for NSIAD ulcer

Research Project

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Project/Area Number 20590718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

FURUTA Takahisa  Hamamatsu University School of Medicine, 医学部付属病院, 准教授 (10303546)

Co-Investigator(Kenkyū-buntansha) IKUMA Mutsuhiro  浜松医科大学, 医学部付属病院, 講師 (00275108)
NISHINO Masafumi  浜松医科大学, 医学部, リサーチアシスタント (10436975)
YAMADE Mihoko  浜松医科大学, 医学部, リサーチアシスタント (10464124)
WATANABE Hiroshi  浜松医科大学, 医学部, 教授 (50262803)
OGAWA Noriyoshi  浜松医科大学, 医学部付属病院, 講師 (80308618)
NANBA Hiroki  浜松医科大学, 医学部, 教授 (60198405)
Project Period (FY) 2008 – 2010
KeywordsNSAID / CYP2C9 / 胃粘膜傷害 / 遺伝子多型 / 個別化療法
Research Abstract

We found that CYP2C9^*3 allele was the risk factor for NSAID ulcer. We also developed the ^<13>C-naproxen breath test, which could easily estimate the activity of CYP2C19 in each subject and be a predictive marker of NSAID-induced gastric lesion.

  • Research Products

    (28 results)

All 2011 2010 2009 Other

All Journal Article (26 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Triple therapy with ecabet sodium, amoxicillin and lansoprazole for 2 weeks as the rescue regimen for H.pylori infection.2011

    • Author(s)
      Furuta T, Kato M, Sugimoto M, Sasaki M, Kamoshida T, Furukawa K., Inaba T, Tomita T, Shirai T, Ishii N, Nomura H, Konda Y, Asaka M, the JAPAN GAST STUDY GROUP.
    • Journal Title

      Intern Med 50

      Pages: 369-374

  • [Journal Article] Influence of different proton pump inhibitors on activity of cytochrome P450 assessed by [^<13>C]-aminopyrine breath test.2011

    • Author(s)
      Kodaira C, Shinya Uchida S, Yamade M, Nishino M, Ikuma M, Namiki N, Sugimoto M, Watanabe H, Hishida A, Furuta T.
    • Journal Title

      J Clin Pharmacol [Epub ahead of print].

  • [Journal Article] Randomised clinical trial : a multicentre, double-blind, placebo-controlled study on the efficacy and safety of rabeprazole 5 mg or 10 mg once daily in patients with non-erosive reflux disease.2011

    • Author(s)
      Kinoshita Y, Ashida K, Hongo M, Japan Rabeprazole Study Group for NERD., Takeda H, Kato M, Shimizu Y, Nakagawa S, Nishi K, Yamauchi M, Eda Y, Ohara S, Koike T, Iijima K, Abe Y, Kusano M, Kawamura O, Shimoyama Y, Sekine C, Miwa J, Uemura N, Akiyama J, Furuta T, Shirai N, Niwa Y, Joh T, Kataoka H, Sasaki M, Wada T, Tanida S, Oshima T, Kasugai K, Konagaya T, Tokura Y, Mitsufuji S, Senoo H, Fujiwara Y, Ashida K, Fukuchi T, Habu Y, Sakaguchi M, Inoue K, Adachi K, Furuta K, Tari A, Tani H, Ishii Y, Shimatani T, Inoue M, Tanaka S, Kitadai Y, Ito M, Hiyama T, Yoshida S, Oka S, Manabe N, Ueno Y, Yoshida T, Ryozawa S, Harada T, Fuji T, Harima K, Murakami A, Nishimura S, Kawamura S, Kuniyoshi N, Kuniyoshi K, Matsui T, Noda T, Umezu T, Koganemaru F, Fujimoto K, Iwakiri R.
    • Journal Title

      Aliment Pharmacol Ther. 33(2)

      Pages: 213-224

  • [Journal Article] Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy.2011

    • Author(s)
      Sugimoto M, Nishino M, Kodaira C, Yamade M, Uotani T, Ikuma M, Umemura K, Furuta T.
    • Journal Title

      World J Gastroenterol. 17(14)

      Pages: 1858-1865

  • [Journal Article] Successful treatment of ulcerative colitis complicated by Sweet's syndrome by corticosteroid therapy and leukocytapheresis.2011

    • Author(s)
      Terai T, Sugimoto M, Osawa S, Sugimoto K, Furuta T, Kanaoka S, Ikuma M.
    • Journal Title

      Clin J Gastroenterol 4

      Pages: 151-156

  • [Journal Article] [13C]-Pantoprazole breath test as the predictor of anti-platelet function of clopidogrel.2010

    • Author(s)
      Furuta T, Iwaki T, Umemura K.
    • Journal Title

      Eur J Clin Pharmacol 66(5)

      Pages: 457-463

  • [Journal Article] Influences of different proton pump inhibitors on the anti-platelet function of clopidogrel in relation to CYP2C19 genotype status.2010

    • Author(s)
      Furuta T, Iwaki T, Umemura K.
    • Journal Title

      Br J Clin Pharmacol. 70(3)

      Pages: 383-392

  • [Journal Article] The dual therapy with 4 times daily dosing of rabeprazole and amoxicillin as the 3rd rescue regimen for eradication of H.pylori2010

    • Author(s)
      Furuta T, Sugimoto M, Kodaira, Nishino M, Yamade M, Uotani T, Ikuma M, Shirai N.
    • Journal Title

      Hepato-Gastroenterology 57(102-103)

      Pages: 1314-1319

  • [Journal Article] Pharmacological aspects of eradication therapy for H.pylori infection.2010

    • Author(s)
      Furuta T, Graham DY.
    • Journal Title

      Gastroenterol Clin North Ame (IF : 2.558) 39

      Pages: 465-480

  • [Journal Article] Esophageal mucosal injury with low-dose aspirin and its prevention by rabeprazole.2010

    • Author(s)
      Sugimoto M, Nishino M, Kodaira C, Yamade M, Ikuma M, Tanaka T, Sugimura H, Hishida A, Furuta T.
    • Journal Title

      J Clin Pharmacol 50(3)

      Pages: 320-330

  • [Journal Article] Relationship between low-dose aspirin-induced gastric mucosal injury and intragastric pH in healthy volunteers.2010

    • Author(s)
      Nishino M, Sugimoto, Kodaira C, Yamade M, Shirai N, Mutsuhiro Ikuma Tanaka T, Sugimura H, Hishida A, Furuta T.
    • Journal Title

      Dig Dis Sci 55(6)

      Pages: 1627-1636

  • [Journal Article] Influence of inflammatory cytokine polymorphisms of IL-2, 4, 6 and 8 on development of gastric cancer and peptic ulcer.2010

    • Author(s)
      Sugimoto M, Yamaoka Y, Furuta T.
    • Journal Title

      World J Gastroenterol 16

      Pages: 1188-1200

  • [Journal Article] Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells.2010

    • Author(s)
      Yamada T, Osawa S, Hamaya Y, Furuta T, Hishida A, Kajimura M, Ikuma M.
    • Journal Title

      Anticancer Res. 30(6)

      Pages: 1953-1960

  • [Journal Article] Preventive Effects of Lansoprazole and Famotidine on Gastric Mucosal Injury Induced by Low-Dose Aspirin in Helicobacter pylori-Negative Healthy Volunteers.2010

    • Author(s)
      Nishino M, Sugimoto M, Kodaira C, Yamade M, Uotani T, Shirai N, Ikuma M, Tanaka T, Sugimura H, Hishida A, Furuta T.
    • Journal Title

      J Clin Pharmacol [Epub ahead of print]

  • [Journal Article] Cecal vanishing tumor associated with cytomegalovirus infection in an immunocompetent elderly adult.2010

    • Author(s)
      Kawasaki S, Osawa S, Sugimoto K, Uotani T, Nishino M, Yamada T, Sugimoto M, Furuta T, Ikuma M.
    • Journal Title

      World J Gastrointest Oncol 2(11)

      Pages: 417-420

  • [Journal Article] CYP2C19 genotype is associated with symptomatic recurrence of GERD during maintenance therapy with low-dose lansoprazole.2009

    • Author(s)
      Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Ikuma M, Shirai N, Watanabe H, Umemura K, Kimura M, Hishida A.
    • Journal Title

      Eur J Clin Pharmacol 65

      Pages: 693-698

  • [Journal Article] [13C]-pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole.2009

    • Author(s)
      Furuta T, Kodaira C, Nishino M, Yamade M, Sugimoto M2), Ikuma M, Hishida A, Watanabe H, Umemura K.
    • Journal Title

      Aliment Pharmacol Ther 30

      Pages: 294-300

  • [Journal Article] Helicobacter pylori and Non-malignant Diseases.2009

    • Author(s)
      Furuta T, Delchier CM.
    • Journal Title

      Helicobacter 14(Suppl.1)

      Pages: 29-35

  • [Journal Article] Risk and benefit of proton pump inhibitor for patients undergoing anti-platelet therapy including clopidogrel.2009

    • Author(s)
      Furuta T.
    • Journal Title

      Intern Med 48(21)

      Pages: 1847-1848

  • [Journal Article] Pharmacogenomics in chemotherapy for GI tract cancer.2009

    • Author(s)
      Furuta T.
    • Journal Title

      J Gastroenterol 44

      Pages: 1016-1025

  • [Journal Article] Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects.2009

    • Author(s)
      Kodaira C, Sugimoto M, Nishino M, Yamade M, Shirai N, Uchida S, Ikuma M, Yamada S, Watanabe H, Hishida A, Furuta T.
    • Journal Title

      Eur J Clin Pharmacol 65

      Pages: 593-600

  • [Journal Article] Cytokine responses of intraepithelial lymphocytes are regulated by histamine H(2) receptor.2009

    • Author(s)
      akagaki K, Osawa S, Horio Y, Yamada T, Hamaya Y, Takayanagi Y, Furuta T, Hishida A, Ikuma M.
    • Journal Title

      J Gastroenterol. 44(4)

      Pages: 285-296

  • [Journal Article] A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy.2009

    • Author(s)
      Kodaira C, Osawa S, Mochizuki C, Sato Y, Nishino M, Yamada T, Takayanagi Y, Takagaki K, Sugimoto K, Kanaoka S, Furuta T, Ikuma M.
    • Journal Title

      World J Gastroenterol. 15(14)

      Pages: 1774-1778

  • [Journal Article] Prospective study of daily low-dose nedaplatin and continuous 5-fluorouracil infusion combined with radiation for the treatment of esophageal squamous cell carcinoma.2009

    • Author(s)
      Osawa S, Furuta T, Sugimoto K, Kosugi T, Terai T, Yamade M, Takayanagi Y, Nishino M, Hamaya Y, Kodaira C, Yamada T, Iwaizumi M, Takagaki K, Yoshida K, Kanaoka S, Ikuma M.
    • Journal Title

      BMC Cancer 9

      Pages: 408

  • [Journal Article] Influence of inflammatory cytokine polymorphisms on eradication rates of Helicobacter pylori.2009

    • Author(s)
      Sugimoto M, Furuta T, Yamaoka Y.
    • Journal Title

      J Gastroenterol Hepatol. 24(11)

      Pages: 1725-1732

  • [Journal Article] Resistance of Helicobacter pylori to quinolones and clarithromycin assessed by genetic testing in Japan.

    • Author(s)
      Yamade M, Sugimoto M, Uotani T, Nishino M, Kodaira C, Furuta T.
    • Journal Title

      J Gastroenterol Hepatol (in press)

  • [Remarks] ホームページ等

  • [Patent(Industrial Property Rights)] 13C-ナプロキセン呼気試験によるNSAID潰瘍リスクの予測法の確立2009

    • Inventor(s)
      古田隆久
    • Industrial Property Rights Holder
      浜松医科大学
    • Industrial Property Number
      特許出願2009-259574
    • Filing Date
      20090000

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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