2010 Fiscal Year Final Research Report
Evaluation of the essential role of Notch signaling in the maintenance of squamous epithelium and the development of adenocarcinoma.
| Project/Area Number |
20590724
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shimane University |
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Principal Investigator |
ISHIMURA Norihisa Shimane University, 医学部, 講師 (40346383)
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| Research Collaborator |
TAMAGAWA Yuji 島根大学, 医学部, 助教 (20609341)
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| Project Period (FY) |
2008 – 2010
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| Keywords | シグナル伝達 / 癌 / Notch / Cdx2 / バレット食道 |
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| Research Abstract |
The roles of Notch signaling in the development of Barrett's esophagus remain obscure. In this study, we have demonstrated that Notch related molecule, Hath-1, played an important role in the development of Barrett's esophagus. In the esophageal squamous epithelium, Hes-1, a downstream target of Notch signaling, was upregulated and blocked Hath-1 expression to maintain homeostasis. However, Cdx2 induced by bile acid exposure to the lower esophagus, leaded to Hes-1 downregulation and Hath-1 upregulation. We have shown that Hath-1 was closely associated with goblet cell differentiation in the development of Barrett's esophagus.
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[Journal Article] A rare case of Barrett's adenocarcinoma including squamous cell carcinoma component.2011
Author(s)
Mishima Y, Amano Y, Yuki T, Kusunoki R, Oka A, Uno G, Ishimura N, Hamaoka M, Ishikawa N, Ishihara S, Kinoshita Y
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Journal Title
Clin J Gastroenterol 4
Pages: 5-9
Peer Reviewed
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[Journal Article] Heparin-binding EGF-like factor augments esophageal epithelial cell proliferation, migration and inhibits TRAIL-mediated apoptosis via EGFR/MAPK signaling.2010
Author(s)
Rahman FB, Ishihara S, Aziz MM, Mishima Y, Oshima N, Li YY, Sanchez-Siles AA, Otani A, Oka A, Kusunoki R, Tada Y, Moriyama I, Ishimura N, Yuki T, Kazumori H, Amano Y, Sato S, Ansary MU, Kinoshita Y
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Journal Title
Scand J Gastroenterol 45
Pages: 1350-1359
Peer Reviewed
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[Journal Article] Fatty acid synthase expression in Barrett's esophagus : implications for carcinogenesis.
Author(s)
Ishimura N, Amano Y, Sanchez-Siles AA, Fukuhara H, Takahashi Y, Uno G, Tamagawa Y, Mishima Y, Yuki T, Ishihara S, Kinoshita Y
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Journal Title
J Clin Gastroenterol (in press)
Peer Reviewed
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[Presentation] HB-EGF Secreted from Subepithelial Fibroblast Cells in Esophagitis Promotes CDx2 Expression in Adjacent Esophageal Squamous Cells via Epithelial-Stromal Crosstalk, Yielding Barrett's Esophagus.2009
Author(s)
Farzana RB, Kadowaki Y, Ishihara S, Tobita H, Imaoka H, Aziz MM, Ishimura N, Furuta K, Amano Y, Kinoshita Y
Organizer
DDW 2009 American Gastroenterological Association
Place of Presentation
Chicago, USA.
Year and Date
2009-06-02
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