2010 Fiscal Year Final Research Report
The role of DNA methylation in development of EBV-associated Gastric cancer
| Project/Area Number |
20590726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
NISHIKAWA Jun Yamaguchi University, 大学院・医学系研究科, 講師 (00379950)
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| Co-Investigator(Kenkyū-buntansha) |
OGA Atsunori 山口大学, 大学院・医学系研究科, 講師 (90243633)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 胃癌 / EBウイルス / DNAメチル化 |
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| Research Abstract |
We studied the role of DNA methylation in development of EBV-associated carcinomas. Several tumor-related genes were methylated in EBV-associated carcinomas. We newly identified 7 genes which are methylated in EBV-associated gastric carcinomas. There are several tumor suppresser genes and tumor associated antigens. Based on these results, we concluded that DNA methylation had an important role for developing EBV-associated gastric carcinomas.
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