2010 Fiscal Year Final Research Report
Study of molecular basis of motilin and growth hormone secretagogue receptors
| Project/Area Number |
20590727
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Ehime University |
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Principal Investigator |
MATSUURA Bunzo Ehime University, 大学院・医学系研究科, 寄附講座教授 (80284420)
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| Research Collaborator |
UEDA Teruhisa 愛媛大学, 大学院
NUNOI Hiroaki 愛媛大学, 大学院
MILLER LJ Mayo Clinic Arizona
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| Project Period (FY) |
2008 – 2010
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| Keywords | モチリン / グレリン |
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| Research Abstract |
Motilin, erythromycin and ghrelin are important endogenous regulators of gastrointestinal motor function, mediated by the class A G protein-coupled motilin receptor and GHS receptor. We have identified new critical residues in the transmembrane domains of the motilin receptor for erythromycin binding and activity using receptor mutagenesis. We have also generated human motilin receptor transgenic mice, and clarified relationship between motilin receptor and GHS receptor.
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Research Products
(20 results)
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[Journal Article] Amino acid imbalance in patients with chronic liver diseases.2010
Author(s)
Michitaka K, Hiraoka A, Kume M, Uehara T, Hidaka S, Ninomiya T, Haseba A, Miyamoto Y, Ichiryu M, Tanihira T, Nakahara H, Ochi H, Tanabe A, Uesugi K, Tokumoto Y, Mashiba T, Abe M, Hiasa Y, Matsuura B, Onji M
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Journal Title
Hepatol Res 40
Pages: 393-398
Peer Reviewed
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[Journal Article]2009
Author(s)
Konishi I, Hiasa Y, Shigematsu S, Hirooka M, Furukawa S, Abe M, Matsuura B, Michitaka K, Horiike N, Onji M
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Journal Title
Liver Int 29
Pages: 1194-1201
Peer Reviewed
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[Presentation] Critical residues in the transmembrane helical bundle domains of the human motilin receptor for erythromycin binding and activity.2009
Author(s)
Matsuura B, Utsunomiya S, Ueda T, Dong M, Miller LJ, Miyake T, Furukawa S, Abe M, Murakami H, Onji M
Organizer
AGA meeting 2009
Place of Presentation
Chicago, USA.
Year and Date
20090531-20090604
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