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2010 Fiscal Year Final Research Report

Study of molecular basis of motilin and growth hormone secretagogue receptors

Research Project

  • PDF
Project/Area Number 20590727
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionEhime University

Principal Investigator

MATSUURA Bunzo  Ehime University, 大学院・医学系研究科, 寄附講座教授 (80284420)

Research Collaborator UEDA Teruhisa  愛媛大学, 大学院
NUNOI Hiroaki  愛媛大学, 大学院
MILLER LJ  Mayo Clinic Arizona
Project Period (FY) 2008 – 2010
Keywordsモチリン / グレリン
Research Abstract

Motilin, erythromycin and ghrelin are important endogenous regulators of gastrointestinal motor function, mediated by the class A G protein-coupled motilin receptor and GHS receptor. We have identified new critical residues in the transmembrane domains of the motilin receptor for erythromycin binding and activity using receptor mutagenesis. We have also generated human motilin receptor transgenic mice, and clarified relationship between motilin receptor and GHS receptor.

  • Research Products

    (20 results)

All 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (5 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Mutational analysis of predicted extracellular domains of human growth hormone secretagogue receptor 1a.2011

    • Author(s)
      Ueda T, Matsuura B, Miyake T, Furukawa S, Abe M, Hiasa Y, Onji M
    • Journal Title

      Regul Pept 166

      Pages: 28-35

    • Peer Reviewed
  • [Journal Article] 消化管ホルモン研究の再来2010

    • Author(s)
      松浦文三, 上田晃久, 宇都宮幸子, 布井弘明, 恩地森一
    • Journal Title

      愛媛医学 29

      Pages: 7-13

  • [Journal Article] Amino acid imbalance in patients with chronic liver diseases.2010

    • Author(s)
      Michitaka K, Hiraoka A, Kume M, Uehara T, Hidaka S, Ninomiya T, Haseba A, Miyamoto Y, Ichiryu M, Tanihira T, Nakahara H, Ochi H, Tanabe A, Uesugi K, Tokumoto Y, Mashiba T, Abe M, Hiasa Y, Matsuura B, Onji M
    • Journal Title

      Hepatol Res 40

      Pages: 393-398

    • Peer Reviewed
  • [Journal Article] Impaired dendritic cell functions disrupt antigen-specific adaptive immune responses in mice with nonalcoholic fatty liver disease.2010

    • Author(s)
      Miyake T, Akbar SM, Yoshida O, Chen S, Hiasa Y, Matsuura B, Abe M, Onji M
    • Journal Title

      J Gastroenterol 45

      Pages: 859-867

    • Peer Reviewed
  • [Journal Article] High orotate phosphoribosyltransferase gene expression predicts complete response to chemoradiotherapy in patients with squamous cell carcinoma of the esophagus.2009

    • Author(s)
      Kajiwara T, Nishina T, Hyodo I, Moriwaki T, Endo S, Nasu J, Hori S, Matsuura B, Hiasa Y, Onji M
    • Journal Title

      Oncology 76

      Pages: 342-349

    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Konishi I, Hiasa Y, Shigematsu S, Hirooka M, Furukawa S, Abe M, Matsuura B, Michitaka K, Horiike N, Onji M
    • Journal Title

      Liver Int 29

      Pages: 1194-1201

    • Peer Reviewed
  • [Journal Article] Changes of anthropometric and biological parameters in patients with non-alcoholic steatohepatitis for dietary modification.2009

    • Author(s)
      Toshimitsu K, Matsuura B, Nagai Y, Miyake T, Ueda T, Furukawa S, Abe M, Hiasa Y, Ebihara K, Onji M
    • Journal Title

      J Metab Clin Nutr 12

      Pages: 337-346

    • Peer Reviewed
  • [Journal Article] Wilms' tumor 1 gene expression is increased in hepatocellular carcinoma and associated with poor prognosis.2008

    • Author(s)
      Sera T, Hiasa Y, Mashiba T, Tokumoto Y, Hirooka M, Konishi I, Matsuura B, Michitaka K, Udaka K, Onji M
    • Journal Title

      Eur J Cancer 44

      Pages: 600-608

    • Peer Reviewed
  • [Journal Article] NIS mRNA expression level in resected thyroid tissue as a marker of postoperative hypothyroidism after subtotal thyroidectomy in patients with Graves' disease.2008

    • Author(s)
      Goto A, Uchino S, Noguchi S, Wakiya S, Watanabe Y, Murakami T, Matsuura B, Onji M
    • Journal Title

      Endocr J 55

      Pages: 73-81

    • Peer Reviewed
  • [Journal Article] Hepatitis C virus replication is inhibited by 22beta-methoxyolean 12-ene-3beta, 24 (4beta)-diol (ME3738) through enhancing interferon-beta.2008

    • Author(s)
      Hiasa Y, Kuzuhara H, Tokumoto Y, Konishi I, Yamashita N, Matsuura B, Michitaka K, Chung RT, Onji M
    • Journal Title

      Hepatology 48

      Pages: 59-69

    • Peer Reviewed
  • [Journal Article] Mutational analysis of the predicted intracellular loop domains of the human motilin receptor.2008

    • Author(s)
      Tokunaga H, Matsuura B, Dong, M, Miller LJ, Ueda T, Furukawa S, Hiasa Y, Onji M
    • Journal Title

      Am J Physiol-Gastrointest Liver Physiol 294

      Pages: 460-466

    • Peer Reviewed
  • [Presentation] A cross-talk between motilin receptor and growth hormone secretagogue receptor using chimeric construct's expression and co-expression.2010

    • Author(s)
      Matsuura B, Utsunomiya S, Ueda T, Miyake T, Furukawa S, Murakami H, Abe M, Hiasa Y, Onji M
    • Organizer
      AGA meeting 2010
    • Place of Presentation
      New Orleans, USA.
    • Year and Date
      20100501-20100505
  • [Presentation] Critical residues in the transmembrane helical bundle domains of the human motilin receptor for erythromycin binding and activity.2009

    • Author(s)
      Matsuura B, Utsunomiya S, Ueda T, Dong M, Miller LJ, Miyake T, Furukawa S, Abe M, Murakami H, Onji M
    • Organizer
      AGA meeting 2009
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      20090531-20090604
  • [Presentation] 消化管運動促進物質モチリン・エリスロマイシンのモチリン受容体におけるシグナル伝達系の解析2008

    • Author(s)
      松浦文三, 上田晃久, 恩地森一
    • Organizer
      JDDW 2008
    • Place of Presentation
      東京
    • Year and Date
      20081001-20081004
  • [Presentation] Identification of peptide-ligand binding domains of the growth hormone secretagogue receptor.2008

    • Author(s)
      Ueda T, Matsuura B, Miyake T, Furukawa S, Hiasa Y, Murakami H, Onji M
    • Organizer
      AGA meeting 2008
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      20080518-20080521
  • [Presentation] New critical residues in the predicted intracellular loop domains of human motilin receptor.2008

    • Author(s)
      Matsuura B, Ueda T, Dong M, Miller LJ, Miyake T, Furukawa S, Onji M
    • Organizer
      AGA meeting 2008
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      20080518-20080521
  • [Book] 肝硬変(NASHを含む).(雨海照祥編:ワンステップ栄養アセスメント応用編)2010

    • Author(s)
      松浦文三, 恩地森一
    • Total Pages
      28-33
    • Publisher
      医歯薬出版,東京
  • [Book] NST臨床栄養療法スタッフマニュアル(ダンピング症候群,便秘,黄疸)(清野裕,門脇孝,中村丁次,本田佳子編)2009

    • Author(s)
      松浦文三, 恩地森一
    • Total Pages
      99-115
    • Publisher
      医学書院,東京
  • [Book] NASH診療best approach(食事療法)(西原利治編)2008

    • Author(s)
      松浦文三, 恩地森一
    • Total Pages
      249-252
    • Publisher
      中外医学社,東京
  • [Remarks] ホームページ等

    • URL

      http://www.m.ehime-u.ac.jp/school/int.med3/

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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