2010 Fiscal Year Final Research Report
The significance of nuclear translocation of transcriptional regulatory factor & tumor suppressor, ATBF1, for the malignant nature of gastric cancer.
| Project/Area Number |
20590731
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
KATAOKA Hiromi Nagoya City University, 大学院・医学研究科, 准教授 (40381785)
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Yutaka 名古屋市立大学, 大学院・医学研究科, 准教授 (90285198)
KAWAGUCHI Makoto 名古屋市立大学, 大学院・医学研究科, 研究員 (50204699)
JOU Takashi 名古屋市立大学, 大学院・医学研究科, 教授 (30231369)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 胃癌 / 転写因子 / 癌抑制因子 / ATBF1 / p53 |
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| Research Abstract |
Transcriptional regulatory factor, ATBF1 associates with RUNX3. The molecular complex of ATBF1 and RUNX3 translocates to the nucleus in response to TGF-β・ signal transduction. ATBF1 and RUNX3 activate the promoter of p21. ATBF1 and RUNX3 complex might function in the nucleus as tumor suppressor and transcriptional regulator.
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Research Products
(6 results)
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[Journal Article] Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF・β signal transduction.2010
Author(s)
Mabuchi M, Kataoka H, Miura Y, Kim TS, Kawaguchi M, Ebi M, Tanaka M, Mori Y, Kubota E, Mizushima T, Shimura T, Mizoshita T, Tanida S, Kamiya T, Asai K, Joh T.
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Journal Title
Biochem Biophys Res Commun. 23;398(2)
Pages: 321-325
Peer Reviewed
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