2010 Fiscal Year Final Research Report
Analysis of the ER molecular chaperone in inflammatory bowel disease.
| Project/Area Number |
20590733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
ITO Takahiro Asahikawa Medical College, 医学部, 特任助教 (30396361)
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| Co-Investigator(Kenkyū-buntansha) |
TANABE Hiroki 旭川医科大学, 医学部, 助教 (50396363)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 免疫学 / 感染症 / 蛋白質 / ストレス |
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| Research Abstract |
The amount of HD5 and HD6 secreted from a single small bowel crypt was estimated. In Crohn's disease patients, the ileal expression of HD5 mRNA was significantly reduced compared with controls. Protein disulfide isomerase (PDI) was expressed in Paneth cells. This study suggested that it was important for disulfide bond formation of defensin. The Paneth cell secretions induced IL-8, TNF-α,IL-1β, IL-13, RANTES and TGF-β1 from T84 cells. Human Paneth cells contribute to innate as well as adaptive immunity by defensin-dependent and -independent processes, which appear to be mediated by induction of pro-inflammatory cytokines. A deficiency of the α-defensins derived from Paneth cells is considered to be associated with various gut diseases, including Crohn's disease.
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Research Products
(12 results)
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[Journal Article] Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice.2010
Author(s)
Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y
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Journal Title
Inflamm Bowel Dis. 16
Pages: 1488-1495
Peer Reviewed
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[Remarks] ホームページ等
