2010 Fiscal Year Final Research Report
Differences of the effect of colonic carcinogenesis by various kinds of fatty acids
| Project/Area Number |
20590745
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Saga University |
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Principal Investigator |
RYUICHI Iwakiri Saga University, 医学部, 准教授 (70232642)
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| Co-Investigator(Kenkyū-buntansha) |
TODA Shuji 佐賀大学, 医学部, 教授 (80188755)
TSUNADA Seiji 佐賀大学, 医学部, 助教 (70264158)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 大腸癌 / 脂肪摂取 / 脂肪酸 |
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| Research Abstract |
We investigated whether various dietary fats affected the colon mucosal growth and tumorigenesis in azoxymethane-treated rats. Rats were supplemented with 10% corn, olive, beef, and fish oil for 44 weeks. Long-term dietary corn oil and beef tallow increased tumor incidence with increased BrdU incorporation. In contrast, both olive and fish oil inhibited them. BrdU-incorporated cells were often observed at tops of crypts in rats fed with beef tallow. Long-term high intake of corn oil and beef tallow enhanced cell proliferation and modulated distribution of proliferating cells, which might contribute to promoting effect in colon tumorigenesis.
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[Journal Article] NSAIDs are a significant risk factor for colonic diverticular hemorrhage in elder patients : Evaluation by a case-control study.2011
Author(s)
Tsuruoka N, Iwakiri R, Hara M, Shirahama N, Sakata Y, Miyahara K, Eguchi Y, Shimoda R, Ogata S, Tsunada S, Sakata H, Fujimoto K.
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Journal Title
J Gastroenterol Hepatol 26
Pages: 1047-1052
Peer Reviewed
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[Journal Article] Chemopreventive effect of mofezolac on beef tallow diet/azoxymethane-induced colon carcinogenesis in rats.2011
Author(s)
Miao L, Shiraishi R, Fujise T, Kuroki T, Kakimoto T, Sakata Y, Takashima T, Iwakiri R, Fujimoto K, Shi R, Li X.
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Journal Title
Hepatogastroenterology. 58
Pages: 81-8
Peer Reviewed
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[Journal Article] The pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease.2011
Author(s)
Eguchi Y, Mizuta T, Sumida Y, Ishibashi E, Kitajima Y, Isoda H, Horie H, Tashiro T, Iwamoto E, Takahashi H, Kwashiorkor T, Soejima S, Kawaguchi Y, Oda Y, Emura S, Iwakiri R, Ozaki I, Euchar T, Ono N, Anza K, Fujimoto K, Koizumi S.
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Journal Title
J Gastroenterol. 46(Suppl.1)
Pages: 70-78
Peer Reviewed
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[Journal Article] Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow.2010
Author(s)
Shiraishi R, Iwakiri R, Fujise T, Kuroki T, Kakimoto T, Takashima T, Sakata Y, Tsunada S, Nakashima Y, Yanagita T, Fujimoto K.
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Journal Title
J.Gastroenterol. 45
Pages: 625-635
Peer Reviewed
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[Journal Article] Age-related fat deposition in multifidus muscle could be a marker for nonalcoholic fatty liver disease.2010
Author(s)
Kitajima Y, Eguchi Y, Ishibashi E, Nakashita S, Aoki S, Toda S, Mizuta T, Ozaki I, Ono N, Eguchi T, Arai K, Iwakiri R, Fujimoto K.
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Journal Title
J Gastroenterol. 45
Pages: 218-224
Peer Reviewed
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