2010 Fiscal Year Final Research Report
Establishment of cancer surveillance using serum anti-p53 antibody in patients with ulcerative colitis
| Project/Area Number |
20590748
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
IWAO Yasushi Keio University, 医学部, 講師 (40168547)
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| Co-Investigator(Kenkyū-buntansha) |
HIBI Toshifumi 慶應義塾大学, 医学部, 教授 (50129623)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Nagamu 慶應義塾大学, 医学部, 講師 (00232546)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 潰瘍性大腸炎 / 大腸癌 / サーベイランス / ELISA / p53 |
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| Research Abstract |
Here we evaluated clinical usefulness of the measurement of anti-p53 antibodies (Abs) by enzyme-linked immunosorbent assay (ELISA) using sera samples from ulcerative colitis (UC) patients. Serum p53 Ab was positive in 15.0% of UC, while it was positive only in 1.6% of HCs. Eight of 13 (61.5%) UC patients with CRC or dysplasia were positive for serum p53 Abs. This study revealed that p53 Ab developed in the progression of UC-associated CRC but not in all patients with neoplasia, suggesting that it is helpful in salvaging patients who drop from a surveillance program.
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Research Products
(8 results)
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[Journal Article] Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis : a Japanese nationwide randomized controlled trial.2011
Author(s)
Watanabe T, Ajioka Y, Matsumoto T, Tomotsugu N, Takebayashi T, Inoue E, Iizuka B, Igarashi M, Iwao Y, Ohtsuka K, Kudo SE, Kobayashi K, Sada M, Matsumoto T, Hirata I, Murakami K, Nagahori M, Watanabe K, Hida N, Ueno F, Tanaka S, Watanabe M, Hibi T
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Journal Title
J Gastroenterol 46Suppl 1
Pages: 11-6
Peer Reviewed
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[Journal Article] Rapid endoscopic improvement is important for 1-year avoidance of colectomy but not for the long-term prognosis in cyclosporine A treatment for ulcerative colitis.2010
Author(s)
Kobayashi T, Naganuma M, Okamoto S, Hisamatsu T, Inoue N, Ichikawa H, Takayama T, Saito R, Sujino T, Ogata H, Iwao Y, Hibi T
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Journal Title
J Gastroenterol 45(11)
Pages: 1129-37
Peer Reviewed
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[Journal Article] Endoscopic and chromoendoscopic atlas featuring dysplastic lesions in surveillance colonoscopy for patients with long-standing ulcerative colitis.2008
Author(s)
Matsumoto T, Iwao Y, Igarashi M, Watanabe K, Otsuka K, Watanabe T, Iizuka B, Hida N, Sada M, Chiba T, Kudo SE, Oshitani N, Nagawa H, Ajioka Y, Hibi T
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Journal Title
Inflamm Bowel Dis 14(2)
Pages: 259-64
Peer Reviewed
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[Journal Article] Lower doses of 6-mercaptopurine/azathioprine bring enough clinical efficacy and therapeutic concentration of erythrocyte 6-mercaptopurine metabolite in Japanese IBD patients.2008
Author(s)
Komiyama T, Yajima T, Kubota R, Iwao Y, Sakuraba A, Funakoshi S, Negishi K, Minami I, Tanaka Y, Mae H, Hibi T
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Journal Title
J Crohns Colitis 2(4)
Pages: 315-21
Peer Reviewed
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