2010 Fiscal Year Final Research Report
Involvement of fatty acids and Kupffer cells for development of liver disease
| Project/Area Number |
20590755
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
FUKUSHIMA Koji Tohoku University, 病院, 助教 (20400476)
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| Research Collaborator |
NORIYUKI Obara 東北大学, 大学院・医学系研究科, 大学院生
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝臓学 |
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| Research Abstract |
We clarified the pathogenic mechanism of trans-fatty acid to the mouse liver summarized as caused by the upregulation of lipogenesis in the liver and elevated level of free fatty acids accompanied by the secretion of TNF-a by Kupffer cells.
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