2010 Fiscal Year Final Research Report
The role of endoplasmic reticulum (ER) stress in non-alcoholic steatohepatitis
| Project/Area Number |
20590758
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Gunma University |
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Principal Investigator |
SATO Ken Gunma University, 医学部, 助教 (40396619)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 発現制御 / ストレス / シグナル伝達 / 遺伝子 / 病理学 |
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| Research Abstract |
The role of endoplasmic reticulum (ER) stress in nonalcoholic steatohepatitis has not been fully elucidated. Because CHOP is one of the ER stress-related molecules, we compared CHOP knock out (KO) mice and wild type (WT) mice in steatohepatitis mice model using a methionine-choline (MCD) deficient diet. Steatosis and neutrophil infiltration, and apoptosis in liver tissue were significantly attenuated in KO mice compared with WT mice at 1 week after the administration of MCD diet. But these significant differences were transient. The time to peak level of the expression of PPAR γ was different between KO mice and WT mice. This may be one of the causes of the difference of pathophysiologic change between KO mice and WT mice.
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