2011 Fiscal Year Final Research Report
The role and crosstalk between nuclear receptors PXR and CAR on the pathogenesis of non-alcoholic steatohepatitis.
| Project/Area Number |
20590759
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHINARI Koichi 東北大学, 薬学研究科(研究院), 准教授 (60343399)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 非アルコール性脂肪性肝炎 / 核内レセプター / CAR / PXR / Cytochrome P450 |
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| Research Abstract |
The roles and crosstalk between nuclear receptors PXR and CAR on the pathogenesis of non-alcoholic steatohepatitis (NASH) were evaluated in this study. CAR accelerated the production of reactive oxygen species (ROS) and worsened the liver injury and fibrosis in the NASH model using methionine-and choline-deficient diet. There were no differences in NASH between PXR knockout and wild-type mice. CAR play a role in the hepatocarcinogenesis of the murine NASH model via the upregulation of cell proliferation.
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