2010 Fiscal Year Final Research Report

Control of chronic hepatitis by splicing variant of hepatitis B virus

Research Project

Project/Area Number	20590763
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Gastroenterology
Research Institution	The University of Tokyo
Principal Investigator	YOTSUYANAGI Hiroshi The University of Tokyo, 医学部附属病院, 准教授 (30251234)
Project Period (FY)	2008 – 2010
Keywords	HBVコア遺伝子 / Splicing Variant / アミノ酸置換
Research Abstract	1. Nucleic or amino acid substitutions in the core gene of hepatitis B virus (HBV) core region were studied. (1) Smaller number of nucleic acid substitutions in the basic core promoter region was associated with inactivation of hepatitis. (2) Larger number of substituted amino acid in the core region was associated with inactivation of hepatitis. 2. The amino acid sequences of HBV splicing variant clones were analyzed. The majority of HBV clones had deletions spanning from end of core to preS-s regions (nt.2448～2934、3019～488). Six splicing patterns were found in the clones, three of which had large deletion (67AA, 87AA) in the core region.

(5 results)