2010 Fiscal Year Final Research Report
Study of Mitochondria dysfunction mechanism caused by HCV infection.
| Project/Area Number |
20590764
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORIYA Kyoji The University of Tokyo, 医学部附属病院, 教授 (00272550)
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| Project Period (FY) |
2008 – 2010
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| Keywords | HCV / ミトコンドリア |
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| Research Abstract |
Liver mitochondria proteomics analysis revealed that HCV core protein directly altered amount of several mitochondria proteins. These proteins may be useful targets of not only new hepatitis C therapy but also of hepatocellular carcinogenesis prevention
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[Journal Article] Pathogenesis of lipid metabolism disorder in hepatitis C : polyunsaturated fatty acids counteract lipid alterations induced by the core protein.2011
Author(s)
Miyoshi H, Moriya K, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Fujinaga H, Goto K, Todoroki T, Suzuki T, Miyamura T, Matsuura Y, Yotsuyanagi H, Koike K.
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Journal Title
J Hepatol. 54(3)
Pages: 432-8
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[Journal Article] Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein : analysis using mouse model and cultured cells.2009
Author(s)
Moriya K, Miyoshi H, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Yotsuyanagi H, Moriishi K, Matsuura Y, Suzuki T, Miyamura T, Koike K.
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Journal Title
Am J Pathol. 175(4)
Pages: 1515-24
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[Journal Article] Tsutsumi T, Matsuda M, Aizaki H, Moriya K, Miyoshi H, Fujie H, Shintani Y, Yotsuyanagi H, Miyamura T, Suzuki T, Koike K.2009
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[Journal Article] Yotsuyanagi H, Kikuchi Y, Tsukada K, Nishida K, Kato M, Sakai H, Takamatsu J, Hige S, Chayama K, Moriya K, Koike K.2009
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