2010 Fiscal Year Final Research Report
Exploitation of the novel therapy for the drug-resistant liver cancer using ultrasonic energy
| Project/Area Number |
20590765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Toyama |
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Principal Investigator |
MINEMURA Masami University of Toyama, 大学病院, 講師 (10313602)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHARA Terumi 富山大学, 大学院・医学薬学研究部(医学), 准教授 (60240777)
SUGUYAMA Toshiro 富山大学, 大学院・医学薬学研究部(医学), 教授 (00196768)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 超音波力学 / 多剤耐性遺伝子 / 肝癌 |
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| Research Abstract |
When the multidrug resistance gene is frequently induced during the chemotherapy of cancer, it is a significant obstacle to successful treatment. In the present study, it has been shown that combination with chemotherapeutic agents and ultrasound (US) causes a synergistic enhancement in killing multidrug-resistant cancer cells, including hepatoma cells. Although the mechanism of the enhanced cytotoxicity using US has not been fully clarified, the possibility exists that increased uptake of drugs is caused by US and enhanced sensitivity to US is related to increased membrane rigidity in the multidrug resistant phenotype.
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