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2010 Fiscal Year Final Research Report

Exploitation of the novel therapy for the drug-resistant liver cancer using ultrasonic energy

Research Project

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Project/Area Number 20590765
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionUniversity of Toyama

Principal Investigator

MINEMURA Masami  University of Toyama, 大学病院, 講師 (10313602)

Co-Investigator(Kenkyū-buntansha) TAKAHARA Terumi  富山大学, 大学院・医学薬学研究部(医学), 准教授 (60240777)
SUGUYAMA Toshiro  富山大学, 大学院・医学薬学研究部(医学), 教授 (00196768)
Project Period (FY) 2008 – 2010
Keywords超音波力学 / 多剤耐性遺伝子 / 肝癌
Research Abstract

When the multidrug resistance gene is frequently induced during the chemotherapy of cancer, it is a significant obstacle to successful treatment. In the present study, it has been shown that combination with chemotherapeutic agents and ultrasound (US) causes a synergistic enhancement in killing multidrug-resistant cancer cells, including hepatoma cells. Although the mechanism of the enhanced cytotoxicity using US has not been fully clarified, the possibility exists that increased uptake of drugs is caused by US and enhanced sensitivity to US is related to increased membrane rigidity in the multidrug resistant phenotype.

  • Research Products

    (2 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Differential cytotoxicity and sonosensitization by sanazole : Effect of cell type and acoustic parameters.2011

    • Author(s)
      Hassan M.A., Furusawa Y., Zhao Q.L., Takasaki I., Ferl L.B.Jr., Tachibana K., Minemura M., Sugiyama T., Kondo T.
    • Journal Title

      J.Med.Ultrasonics. 38

      Pages: 65-72

    • Peer Reviewed
  • [Presentation] Effects of low-intensity ultrasound on drug-sensitive MES-SA and multidrug resitant MES-SA/DX5 uterine sarcoma cells.2010

    • Author(s)
      Hassan M.A., Minemura M., Kondo T.
    • Organizer
      10th International Symposium on Therapeutic Ultrasound (ISTU2010)
    • Place of Presentation
      Tokyo.
    • Year and Date
      20100609-20100612

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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