2010 Fiscal Year Final Research Report
Comprehensive gene expression analysis of cancer-infiltrating lymphocytes and peripheral blood cells for elucidation of cancer immunity kinesis
| Project/Area Number |
20590766
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kanazawa University |
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Principal Investigator |
SAKAI Yoshio Kanazawa University, 医学系, 准教授 (80401925)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝臓学 / 遺伝子発現 |
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| Research Abstract |
Using murine subcutaneous hapatoma model which shows the proliferating and succeeding extinguishing phases, analysis of gene expression profile for local cancer-infiltrating inflammatory cells as well as peripheral blood cells was performed. The features of gene expression profiles for peripheral blood were distinct depending on the groups divided by the days after cancer cells injection. The common feature of gene expression of local cancer-infiltrating inflammatory cells as well as peripheral blood cells for mice with the tumors at the maximum size levels showed IL-6 signal and response to unfoleded proteins. As for the individually characteristic processes of gene expression, interferon signaling, NK cell cytotoxicity, complement system for local cancer-infiltrating inflammatory cells, and IL-10 anti-inflammatory response, amphoterin signaling for peripheral blood, were featured, respectively. These suggest that comprehensive analysis of gene expression of local cancer inflammatory response and peripheral blood cells will reveal the common as well as the distinguished features of local and systemic inflammatory responses.
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[Journal Article] Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C.2010
Author(s)
Honda M, Nakamura M, Tateno M, Sakai A, Shimakami T, Shirasaki T, Yamashita T, Arai K, Yamashita T, Sakai Y, Kaneko S.
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Journal Title
J Hepatol. vol.53
Pages: 817-826
Peer Reviewed
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[Journal Article] Hokuriku Liver Study Group. Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C.2010
Author(s)
Honda M, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, SakaiY, Yamashita T, Nakamura M, Shirasaki T, Horimoto K, Tanaka Y, Tokunaga K, Mizokami M, Kaneko S
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Journal Title
Gastroenterology vol.139
Pages: 499-509
Peer Reviewed
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[Journal Article] Hokuriku Liver Study Group. Differential Gene Expression Profiling in Blood from Patients with Digestive System Cancers.2010
Author(s)
Honda M, Sakai Y, Yamashita T, Yamashita T, Sakai A, Mizukoshi E, Nakamoto Y, Tatsumi I, Miyazaki Y, Tanno H, Kaneko S
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Journal Title
Biochem Biophys Res Commun vol.400
Pages: 7-15
Peer Reviewed
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