2010 Fiscal Year Final Research Report
Data mining analysis for the investigation of clinical features of chronic hepatitis C
| Project/Area Number |
20590768
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KUROSAKI Masayuki University of Yamanashi, 大学院・医学工学総合研究部, 医学研究員 (10280976)
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| Co-Investigator(Kenkyū-buntansha) |
IZUMI Namiki 山梨大学, 大学院・医学工学総合研究部, 医学研究員 (20397300)
ENOMOTO Nobuyuki 山梨大学, 大学院・医学工学総合研究部, 教授 (20251530)
ASAHINA Yasuhiro 山梨大学, 大学院・医学工学総合研究部, 医学研究員 (00422692)
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| Project Period (FY) |
2008 – 2010
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| Keywords | データ・マイニング / C型肝炎 / 肝がん / インターフェロン / 個別化診療 |
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| Research Abstract |
We have analyzed factors that are predictive of response to peg-interferon plus ribavirin in chronic hepatitis C using data mining method. We found that hepatic steatosis, lower LDL-cholesterol level, higher glucose level and higher GGT level was predictive of poor virological response during the early treatment period. The HCV sequences in the ISDR and Core 70 was predictors of response independently of other factors. In 2009, a SNP near the IL28B was found to be most closely associated with the response to interferon therapy. We found that while IL28B was associated with the probability of viral decline, ISDR was a predictor of SVR independently of IL28B since ISDR was related to relapse of hepatitis. In the search for the factors associated with HCC development, lower albumin, higher FIB-4 index, hepatic steatosis and hyperglycemia was identified as a significant predictor. Hyperglycemia and hepatic steatosis was related to HCC development independent of liver fibrosis. Whether thee metabolic features could be the target for therapeutic intervention to reduce the incidence of HCC awaits further investigation.
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[Journal Article] Changes in hepatitis C viral load during first 14 days can predict the undetectable time point of serum viral load by pegylated interferon and ribavirin therapy.2011
Author(s)
Itakura J, Asahina Y, Tamaki N, Hirayama I, Yasui Y, Tanaka T, Sato M, Ueda K, Kuzuya T, Tsuchiya K, Nakanishi H, Kurosaki M, Gabriel GS, Schneider GJ, Izumi N.
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Journal Title
Hepatol Res 41
Pages: 217-224
Peer Reviewed
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[Journal Article] Pretreatment Prediction of Response to Pegylated-Interferon Plus Ribavirin for Chronic Hepatitis C using Genetic Polymorphism in IL28B and Viral Factors.2011
Author(s)
Kurosaki M, Tanaka Y., Nishida N., Sakamoto N,, Enomoto, N., Honda, M.、Sugiyama M., Matsuura, K., Sugauchi, K., Asahina Y, Nakagawa, M., Watanabe, M., et al.
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Journal Title
Peer Reviewed
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[Journal Article] Hepatic steatosis in chronic hepatitis C is a significant risk factor for developing hepatocellular carcinoma independent of age, sex, obesity2010
Author(s)
Kurosaki M., Hosokawa, T., Matsunaga, K., Hirayama, I., Tanaka, T., Sato, M., Yasui, Y., Tamaki, N., Ueda, K.,Tsuchiya, K., Kuzuya, T., Nakanishi, H., Itakura, J., Takahashi, Y, Asahina, Y, Enomoto, N, Izumi, N
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Journal Title
fibrosis stage and response to interferon therapy Hepatol Res. 40
Pages: 870-877
Peer Reviewed
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[Journal Article] Effect of aging on risk for hepatocellular carcinoma in chronic hepatitis C virus infection.2010
Author(s)
Asahina Y, Tsuchiya K, Tamaki N, Hirayama I, Tanaka T, Sato M, Yasui Y, Hosokawa T, Ueda K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Izumi N.
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Journal Title
Hepatology 52
Pages: 518-527
Peer Reviewed
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[Journal Article] Miyake S Potential relevance of cytoplasmic viral sensors and related regulators involving innate immunity in antiviral response.2008
Author(s)
Asahina Y, Izumi N, Hirayama I, Tanaka T, Sato M, Yasui Y, Komatsu N, Umeda N, Hosokawa T, Ueda K, Tsuchiya K, Nakanishi H, Itakura J, Kurosaki M, Enomoto N, Tasaka M, Sakamoto N,
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Journal Title
Gastroenterology 134
Pages: 1396-1405
Peer Reviewed
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