2010 Fiscal Year Final Research Report
Impact of gene silencing on the recurrence of hepatocellular carcinoma after living-donor liver transplantation
| Project/Area Number |
20590772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
NISHIMURA Takafumi Kyoto University, 医学研究科, 特定講師 (40378732)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Yoshihiro 京都大学, 大学院・医学研究科, 教授 (50127130)
NISHIDA Naoshi 京都大学, 大学院・医学研究科, 助教 (60281755)
UEDA Mikiko 京都大学, 大学院・医学研究科, 講師 (20322159)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝臓学 |
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| Research Abstract |
This study was conducted to elucidate whether epigenetic silencing of tumor suppressor genes in the tumor predict the recurrence of hepatocellular carcinoma after living-donor liver transplantation. Tumor and non-tumor tissues were obtained from 50 patients and promoter methylations of APC, CDKN2A, RASSF1A, HIC1, GSTP1, RUNX3, PRDM2, and SOCS1 were examined by combined bisulfite restriction analysis method (COBRA). Although higher levels of promoter methylation in tumor than non-tumor were noted, none of these were correlated to the recurrence of hepatocellular carcinoma.
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