2010 Fiscal Year Final Research Report
Role of adiponectin in the development of liver cancer
Project/Area Number |
20590775
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Osaka University |
Principal Investigator |
YOSHIDA Yuichi Osaka University, 医学系研究科, 助教 (30457014)
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Co-Investigator(Kenkyū-buntansha) |
KISO Shinichi 大阪大学, 医学系研究科, 助教 (40335352)
WATABE Kenji 大阪大学, 医学系研究科, 助教 (50379244)
TSUTSUI Syusaku 大阪大学, 医学系研究科, 助教 (10359846)
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Project Period (FY) |
2008 – 2010
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Keywords | 肝発癌 / メタボリックシンドローム / アディポネクチン |
Research Abstract |
Recently, the metabolic syndrome, a cluster of metabolic disorders often associated with visceral obesity, is reported to increase the risk of hepatocarcinogenesis. Although adiponectin is a plasma protein secreted from adipose tissue with known anti-diabetic and anti-atherogenic properties, its role in the development of liver cancer has remained unclear. In our current study, we investigated the growth of the transplanted liver tumors in the adiponectin knock out (KO) mice and demonstrated that KO mice showed the increased proliferation of liver tumors. These data indicated the possible anti-tumor role of adiponcetin in the development of liver cancer.
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Research Products
(31 results)
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[Presentation] Gab1 scaffolding adaptor protein is required for stem/progenitor cell mediated liver regeneration in mice.2010
Author(s)
Yoshida Y, Kizu T, Tsubakio M, Chatani N, Hamano M, Takemura T, Ezaki H, Kamada Y, Kiso S, Hayashi N.
Organizer
AASLD 2010 Boston, MA, USA, Hynes Convention Center
Place of Presentation
Parallel session(口頭発表)
Year and Date
2010-11-01
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[Remarks] 特になし