2010 Fiscal Year Final Research Report
Analysis of NASH pathophysiology using glycobiological technique
| Project/Area Number |
20590777
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
HIRAMATSU Naoki Osaka University, 医学系研究科, 講師 (30362700)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Hitoshi 大阪大学, 医学系研究科, 助教 (80467505)
MIYOSHI Eiji 大阪大学, 医学系研究科, 教授 (20322183)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝臓学 |
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| Research Abstract |
N-Acetylglucosaminyltransferase V (GnT-V), catalyzing beta1-6 branching in asparagine-linked oligosaccharides, is known to promote cancer metastasis, and its expression is increased in chronic hepatitis (CH) progression. Using GnT-V transgenic (Tg) mice, we found GnT-V prevented hepatic inflammation and fibrosis in a mouse CH model through modulation of lymphocyte and HSC function. Moreover, we also found GnT-V prevented hepatocyte cholesterol accumulation which led to ameliorate hepatocyte sensitivity to inflammation. These results indicated expression of GnT-V in CH would prevent disease progression as a self-defense reaction.
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