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2011 Fiscal Year Final Research Report

The association of extracellular matrix metabolism-related gene polymorphisms with hepatic fibrosis progression and hepatocarcinogenesis in HCV chronic liver disease

Research Project

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Project/Area Number 20590779
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTottori University

Principal Investigator

MURAWAKI Yoshikazu  鳥取大学, 医学部, 教授 (90144659)

Project Period (FY) 2008 – 2011
Keywords遺伝子多型 / C型肝炎 / 肝線維化 / 肝発癌 / 肝細胞癌
Research Abstract

In chronic hepatitis C, the risk of developing hepatocellular carcinoma increases with the progression of liver fibrosis, especially higher in cirrhosis. It is necessary to degrade the surrounding fibrosis matrix of tumor for growth, invasion, and metastasis of malignant tumors, in which matrix metalloproteinases are strongly involved. Recently, functional gene polymorphisms have been identified in matrix metalloproteinases, tissue inhibitors of metalloproteinases and fibrosis-related cytokines. In this study, we analyzed these functional gene polymorphisms as the host genetic factors, and examined the association of these polymorphisms with the severity of liver fibrosis and the prognosis of hepatocellular carcinoma in chronic liver diseases C.

  • Research Products

    (15 results)

All 2011 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (9 results)

  • [Journal Article] Functional gene polymorphisms of interleukin-10 are associated with liver disease progression in Japanese patients with hepatitis C virusu infection2011

    • Author(s)
      Ishida C, Ikebuchi Y, Okamoto K, Murawaki Y
    • Journal Title

      Inter Med

      Volume: 50 Pages: 659-666

    • Peer Reviewed
  • [Journal Article] The genotypes of IL-1 betat and MMP-3 are associated with the prognosis of HCV-related hepatocellular carcinoma2010

    • Author(s)
      Okamoto K, Ishida C, Ikebuchi Y, Mandai M, Mimura K, Murawaki Y, Yuasa I.
    • Journal Title

      Inter Med

      Volume: 49 Pages: 887-895

    • Peer Reviewed
  • [Journal Article] TIMP-2遺伝子多型と肝線維化進行2010

    • Author(s)
      池渕雄一郎、石田千尋、岡本欣也、村脇義和
    • Journal Title

      薬理と治療

      Volume: 38 Pages: 143-145

  • [Journal Article] サイトカインおよびMMPの遺伝子多型とHCV関連肝細胞癌との関連2009

    • Author(s)
      岡本欣也、石田千尋、池淵雄一郎、万代真理、三村憲一、村脇義和
    • Journal Title

      薬理と治療

      Volume: 37 Pages: 129-136

  • [Journal Article] Interleukin-10遺伝子多型と肝線維化進行2009

    • Author(s)
      石田千尋、池淵雄一郎、岡本欣也、村脇義和
    • Journal Title

      薬理と治療

      Volume: 37 Pages: 89-92

  • [Journal Article] 肝線維化および肝発癌とMMP-7遺伝子多型との関連2008

    • Author(s)
      前田直人、大谷英之、万代真理、岡本欣也、村脇義和
    • Journal Title

      薬理と治療

      Volume: 36 Pages: 173-176

  • [Presentation] C型慢性肝疾患におけるTIMP-2遺伝子多型と肝線維化進行との関連2011

    • Author(s)
      池淵雄一郎、石田千尋、岡本欣也、村脇義和
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-03
  • [Presentation] The association of TIMP-1 and TIMP-2 gene polymorphisms with the fibrosis progression in chronic liver disease C2011

    • Author(s)
      Ikebuchi Y, Ishida C, Okamoto K, Murawaki Y
    • Organizer
      EASL 2011
    • Place of Presentation
      Berlin
    • Year and Date
      2011-03-31
  • [Presentation] C型慢性肝炎における肝線維化進行とTIMP-2遺伝子多型との関連2010

    • Author(s)
      池淵雄一郎、石田千尋、岡本欣也、村脇義和
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形
    • Year and Date
      2010-05-27
  • [Presentation] IL-10およびTIMP-2遺伝子多型とHCV関連肝細胞癌との関連2010

    • Author(s)
      岡本欣也、石田千尋、池淵雄一郎、村脇義和
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2010-04-23
  • [Presentation] Association of functional gene polymorphisms of Interleukin-10 with the progression of liver fibrosis in Japanese patients with hepatitis C virus-related chronic liver disease2010

    • Author(s)
      Ishida C, Ikebuchi Y, Okamoto K, Murawaki Y
    • Organizer
      EASL 2010
    • Place of Presentation
      Vienna
    • Year and Date
      2010-04-16
  • [Presentation] The association of IL-10 and TIMP-2 gene polymorphisms with HCC carcinogenesis and the prognosis in chronic hepatitis C patients2010

    • Author(s)
      Okamoto K, Ikebuchi Y, Ishida C, Murawaki Y.
    • Organizer
      EASL 2010
    • Place of Presentation
      Vienna
    • Year and Date
      2010-04-16
  • [Presentation] C型慢性肝炎での肝線維化進行Interleukin-10遺伝子多型との関連2009

    • Author(s)
      石田千尋、池淵雄一郎、岡本欣也、村脇義和
    • Organizer
      第45階日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-14
  • [Presentation] IL-1β、IL-1R RN、TGF-β1、MMP-1、-2、-3、-7、-9の遺伝子多型とHCV関連肝細胞癌との関連2009

    • Author(s)
      岡本欣也、石田千尋、池淵雄一郎、大谷英之、万代真理、三村憲一、前田直人、村脇義和
    • Organizer
      第45階日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-04
  • [Presentation] The genotypes of interleukin 1 beta, transforming growth factor beta 1 and matrix metalloproteinase 3 are associated with the prognosis of HCV related hepatocellular carcinoma patients2008

    • Author(s)
      Okamoto K, Manadai M, Ootani H, Mimura K, Maeda N, Murawaki Y
    • Organizer
      16^<th> UEGW
    • Place of Presentation
      Vienna
    • Year and Date
      2008-10-21

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Published: 2013-07-31  

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