2010 Fiscal Year Final Research Report
Development of a novel therapy using the iron chelator for advanced hepatocellular carcinoma
| Project/Area Number |
20590783
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
YAMASAKI Takahiro Yamaguchi University, 医学部付属病院, 准教授 (00304478)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAIDA Isao 山口大学, 大学院・医学系研究科, 教授 (80263763)
TERAI Shuji 山口大学, 大学院・医学系研究科, 准教授 (00332809)
YAMAMOTO Naoki 山口大学, 大学教育機構, 講師 (90448283)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝細胞癌 / 鉄キレート剤 / 肝発癌 |
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| Research Abstract |
We investigated the anti-tumor effect and the fibrosing suppression effect of the iron chelator deferoxamine (DFO) in vitro and in the model rats using diethylnitrosamine and choline-deficient L-amino acid-defined diet. We proved the antiproliferative effect of DFO in hepatoma cell line. In the vivo model, the body weight and liver weight in the DFO therapy group was significantly lower than those in the control group, and the tumor growth was significantly suppressed in the DFO therapy group comparing the control group. The iron chelator has few DNA damage and has the potential of hepatma specific action different from the traditional anticancer drugs. In this study, we founded that the iron chelator has the potential of a novel antiproliferative drug in patients who had advanced hepatocellular carcinoma and were non-responders for anticancer drugs.
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