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2010 Fiscal Year Final Research Report

The importance of 2 dimensional dysfunction of Kupffer cells for the pathogenesis of nonalcoholic steatohepatitis

Research Project

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Project/Area Number 20590785
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKochi University

Principal Investigator

ONO Masafumi  Kochi University, 教育研究部・医療学系, 講師 (70304681)

Co-Investigator(Renkei-kenkyūsha) SAIBARA TOSHIJI  高知大学, 教育研究部・医療学系, 教授 (60145125)
Project Period (FY) 2008 – 2010
KeywordsNASH / NAFLD / Kupffer細胞 / エンドトキシン
Research Abstract

The pathogenesis of nonalcholic steatohepatitis (NASH) has not been well understood yet. Recently, it is reported that the dysfunctional of Kupffer cells would be involved the pathogenesis of NASH. Therefore, we clarified the impairment of the Kupffer cells' phagocytic function in NASH rats by the fluorescent beads uptake examination and SPIO-MRI examination. In addition, the impairment of the Kupffer cells' phagocytic function in NASH patients was also shown by SPIO-MRI. Taken together these results, it was important pathogensis in NASH of which co-existence of the activated cytokines release from Kupffer cells and impaired phagocytic function of Kupffer cells.

  • Research Products

    (21 results)

All 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (11 results) Book (4 results) Remarks (1 results)

  • [Journal Article] A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet.2011

    • Author(s)
      Ogasawara M, Hirose A, Ono M
    • Journal Title

      Liver Int. 31(4)

      Pages: 542-551

    • Peer Reviewed
  • [Journal Article] The latest idea in NAFLD/NASH pathogenesis.2011

    • Author(s)
      Ono M, Okamoto N
    • Journal Title

      Clin J Gastroenterol. (3)

      Pages: 263-270

    • Peer Reviewed
  • [Journal Article] Super paramagnetic iron Oxide MRI shows defective kupffer cell uptake function in non-alcoholic fatty liver disease.2010

    • Author(s)
      Asanuma T, Ono M, Kubota K, Saibara T
    • Journal Title

      Gut 59

      Pages: 258-266

    • Peer Reviewed
  • [Journal Article] 日本肝臓学会コンセンサス神戸2009:NASHの診断と治療2009

    • Author(s)
      岡上武, 西原利治, 小野正文
    • Journal Title

      肝臓 50(特別寄稿)

      Pages: 741-747

  • [Journal Article] Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD ) : A simple clinical scoring system using ferritin, fasting, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease.

    • Author(s)
      Sumida Y, Ono M, Saibara T, Kawada N
    • Journal Title

      J Gastroenterol [Epub ahead of print] [IF:2.909]

    • Peer Reviewed
  • [Presentation] Angiotensinogen gene haplotype associate with the prevalence of Japanese NASH.2011

    • Author(s)
      小野正文
    • Organizer
      46th annual meeting of the European Association for the Study of the Liver. Poster
    • Place of Presentation
      Berlin Germany.
    • Year and Date
      20110330-20110403
  • [Presentation] クラウド・コンピューティングを駆使した遠隔地の多施設共同研究の試み-Japan Study Group for NAFLD (JSG-NAFLD)の試み2010

    • Author(s)
      小野正文
    • Organizer
      第5回医療の質・安全学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2010-11-27
  • [Presentation] 遺伝子ハプロタイプから見たNASH治療標的としてのangiotensinogen2010

    • Author(s)
      小野正文
    • Organizer
      第14回肝臓学会大会、第52回日本消化器病学会大会合同シンポジウム
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2010-10-14
  • [Presentation] 非アルコール性脂肪性肝疾患と高尿酸血症に対するエストロゲンの影響について2010

    • Author(s)
      小野正文
    • Organizer
      第6回消化器病における性差医学・医療研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-17
  • [Presentation] Gold-thioglucose with high fat dies provides comprehensive mice models of NASH.2010

    • Author(s)
      小野正文
    • Organizer
      45^<th> Annual Meeting of the European Association for the Study of the Liver.
    • Place of Presentation
      Reed Messe Wien Exhibition & Congress Center (Austria)
    • Year and Date
      2010-04-14
  • [Presentation] 検診受診者におけるNASHの高リスク群の同定2009

    • Author(s)
      小野正文
    • Organizer
      第51回日本消化器病学会大会.シンポジウム「メタボリック症候群における肝障害」
    • Place of Presentation
      京都
    • Year and Date
      20090000
  • [Presentation] 1231-BMIPP肝脂肪酸代謝シンチを用いた非アルコール性脂肪肝炎(NASH)の脂肪酸β酸化の解析とその有用性について.2009

    • Author(s)
      小野正文
    • Organizer
      第38回日本肝臓学会西部会.シンポジウム「NASH研究の最前線」
    • Place of Presentation
      鳥取
    • Year and Date
      2009-12-04
  • [Presentation] Novel comprehensive animal models of NASH treated with gold-thioglucose.2009

    • Author(s)
      小野正文
    • Organizer
      The 60th Annual meeting of the American Association for the study of Liver Disease. Poster
    • Place of Presentation
      Boston USA.
    • Year and Date
      2009-11-02
  • [Presentation] The evaluation of hepatic mitochondrial fatty acid beta-oxidation in nash patients using ^<123>I-BMIPP scintigraphy.2009

    • Author(s)
      小野正文
    • Organizer
      EASL special conference NAFLD/NASH and related metabolic disease. Poster
    • Place of Presentation
      Bologna Italy
    • Year and Date
      2009-09-25
  • [Presentation] NASHの発症機序2009

    • Author(s)
      小野正文
    • Organizer
      第45回日本肝臓学会総会.コンセサスミーティング「NASH」
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-04
  • [Presentation] ゴルジ装置の機能に影響を与える遺伝子の遺伝子多型は風船様肝細胞の危険因子である2009

    • Author(s)
      小野正文
    • Organizer
      第95回日本消化器病学会総会.ワークショップ「NAFLDの経時的進展」
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-09
  • [Book] Annual Review(6非アルコール性脂肪性肝疾患)(林紀夫・日比紀文・上西紀夫・下瀬川徹編)2011

    • Author(s)
      小野正文
    • Total Pages
      146-151
    • Publisher
      他中外医学社
  • [Book] NASH(非アルコール性脂肪肝炎)(薬局増刊号病気と薬パーフェクトブック)2010

    • Author(s)
      西原利治, 小野正文
    • Total Pages
      464-465
    • Publisher
      南山堂
  • [Book] 現場の疑問に答える(肝臓病診療Q&A)2009

    • Author(s)
      西原利治, 小野正文
    • Total Pages
      231-233
    • Publisher
      中外医学社
  • [Book] 薬局増刊号病気と薬パーフェクトBOOK2009

    • Author(s)
      西原利治, 小野正文
    • Total Pages
      384-386
    • Publisher
      南山堂
  • [Remarks] ホームページ等

    • URL

      http://www.kochilnai.jp/

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Published: 2012-01-26   Modified: 2016-04-21  

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