2009 Fiscal Year Final Research Report
Clarification of liver condition progress mechanism that uses Hepatitis B virus reproduction model
| Project/Area Number |
20590789
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
TANAKA Yasuhito Nagoya City University, 大学院・医学研究科, 教授 (90336694)
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| Project Period (FY) |
2008 – 2009
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| Keywords | HBV / 肝発癌 / 共感染 / キメラマウス |
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| Research Abstract |
(1) Mechanism of hepatitis B virus (HBV) infection and replication : (1)HBV core protein as well as core promoter mutations are associated with viral replication. (2)The replication of genotype G was supported by core proteins of the other genotypes. (3)The hollow-fiber 3D culture system is superior to conventional monolayer culture allowing maintenance of HBV replication for a substantially longer duration. (2) Clarification of liver condition progress mechanism : Infection with HBV/C2 as well as PC mutant in immunosuppressive conditions can induce direct cytopathic effect in "humanized" part of the murine liver due to the activation of hepatic stellate cells mediated by oxidative stress.
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