Analysis of newly recognized amplified region in 1q21p in hepatocellular carcinoma

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590790
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: ITOH Yoshito 京都府立医科大学, 医学研究科, 准教授 (70244613)
• Co-Investigator(Kenkyū-buntansha): YASUI Kohichiroh 京都府立医科大学, 医学研究科, 准教授 (30323695)
• Project Period (FY): 2008 – 2010
• Keywords: 肝臓学

Research Abstract

We believed that the changes in the genomes derived from HCC were deeply involved in the growth or malignant transformation of HCC cells. We have already reported that CREB3L4(cyclic AMP responsive element binding protein 3-like 4) located in 1q21p, which belonged to the CREB/ATF family, was amplified and was expressed in high levels in HCC samples. In the process of further research, we found that the nuclear expression of P300, a transcriptional co-factor, was associated with the vascular invasion and intrahepatic metastasis of human HCCs. Furthermore, we identified that high expression of P300 in HCC was associated with epithelial mesenchymal transition-like phenotypic change and cyclin D1/beta-catenin dependent growth of HCC cells which might explain the poor prognosis of the patients.

Research Products

• [Journal Article] High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells (2011)
  • Author(s): Yokomizo C, Yamaguchi K, Itoh Y, Nishimura T, Minami M, Yasui K, Mitsuyoshi H, tochiki N, Fujii H, Nakajima T, Umemura A, Okanoue T, Yoshikawa T
  • Journal Title: Cancer Lett Volume: 310 Pages: 140-147
  • Peer Reviewed
• [Presentation] High expression of P300 in HCC is associated with EMT-like phenotypic change and cyclin D1/beta-catenin dependent growth of HCC cells which may underlie poor prognosis of the patients (2011)
  • Author(s): Yokomizo C, Yamaguchi K, Nishimura T, N Tochiki, Fujii H, Nakajima T, Umemura A, Okanoue T, Itoh Y
  • Organizer: 62th Annual Meeting of the American Association for the Study of Liver Disease(AASLD)
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20111104-08
• [Presentation] 細胞癌におけるtranscriptional cofactor P300の発現とその臨床的意義 (2011)
  • Author(s): 横溝千尋、山口寛二、新美敏久、西村健、藤井秀樹、吉川敏一、伊藤義人
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 20110602-03
• [Presentation] High Expression of A Transcriptional Cofactor P300 in HCC Down-Regulates E-Cadherin, Promotes Tumor Invasion, And Predicts Shortened Overall Survival Of HCC Patients (2010)
  • Author(s): Yokomizo C, Itoh Y, Yamaguchi k, Nishimura T, Okanoue T, Yoshikawa T
  • Organizer: 61th Annual Meeting of the American Association for the Study of Liver Disease(AASLD)
  • Place of Presentation: Boston, USA
  • Year and Date: 20101029-1102