2010 Fiscal Year Final Research Report
Determination of ADAMTS13 and its regulation mechanism in severe liver disturbance
| Project/Area Number |
20590794
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
UEMURA Masahito Nara Medical University, 医学部, 准教授 (90151836)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Masanori 奈良県立医科大学, 医学部, 准教授 (60316081)
FUKUI Hiroshi 奈良県立医科大学, 医学部, 教授 (80145838)
FUJIMURA Yoshihiro 奈良県立医科大学, 医学部, 教授 (80118033)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | ADAMTS13 / 肝星細胞 / 微小循環障害 / 多臓器不全 / 肝不全 / 肝硬変 / 劇症肝炎 / アルコール性肝炎 / インヒビター |
|---|
| Research Abstract |
ADAMTS13 is a metalloproteinase produced exclusively in hepatic stellate cells and specifically cleaves highly multimeric von Willebrand factor (VWF). Deficiency of ADAMTS13 results in accumulation of unusually large VWF multimers (UL-VWFM) in plasma, in turn induces platelet clumping or thrombi under high shear stress, followed by microcirculatory disturbances. The present study is to elucidate further understanding of the pathophysiology of liver injury and hepatic failure from the point of the decrease in ADAMTS13 and the increase in VWF-dependent platelet aggregations and subsequent sinusoidal microcirculatory disturbance and multiorgan failure. These investigations based on the determination of ADAMTS13 and its regulation promise to bring further understanding of the pathogenesis of advanced liver disturbances, and offer new insight for development of therapeutic strategies.
|
