2010 Fiscal Year Final Research Report
Fundamental study for development of a peptide vaccine against hepatitis C virus
| Project/Area Number |
20590799
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
YAMADA Akira Kurume University, 先端癌治療研究センター, 教授 (50158177)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ウイルス / 感染症 / 免疫学 |
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| Research Abstract |
Fundamental studies for development of therapeutic and prophylactic vaccines against hepatitis C and liver cancers.
(1) New immuno-potentiator (adjuvant) was developed and its safety and immune-potentiating activity have been demonstrated in both animal and human.
(2) Hepatitis C vaccine applicable for virtually 100% of HLA types of Japanese was developed and its safety and immunological effects have been demonstrated in human clinical trials.
(3) Decrease of virus RNA and normalization of liver function (ALT) were observed in clinical trials. Prophylactic effect of vaccination against carcinogenesis and recurrence of HCV-related liver cancers was also observed.
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Research Products
(47 results)
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[Journal Article] Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination.2011
Author(s)
Noguchi M, Mine T, Komatsu N, Suekane S, Moriya F, Matsuoka K, Yutani S, Shichijo S, Yamada A, Toh U, Kawano K, Azuma K, Uemura H, Okuno K, Matsumoto K, Yanagimoto H, Yamanaka R, Oka M, Todo S, Sasada T, Itoh K.
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Journal Title
Cancer Biol Ther. 12;10(12)
Pages: 1266-79
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[Journal Article] Phase I trial of a personalized Peptide vaccine for patients positive for human leukocyte antigen--A24 with recurrent or progressive glioblastoma multiforme.2011
Author(s)
Terasaki M, Shibui S, Narita Y, Fujimaki T, Aoki T, Kajiwara K, Sawamura Y, Kurisu K, Mineta T, Yamada A, Itoh K.
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Journal Title
J Clin Oncol. 20;29(3)
Pages: 337-44
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[Journal Article] Phase-I clinical study of a personalized peptide vaccination available for six different HLA (HLA-A2, -A3, -A11, -A24, -A31, and -A33)-positive patients with advanced cancer.2011
Author(s)
Yamada A, Noguchi M, Komatsu N, Suekane S, Yutani S, Moriya F, Mine T, Momozono K, Kawano K, Itoh K.
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Journal Title
Exp Ther Med. 2
Pages: 109-117
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[Journal Article] Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis Cvirus.2010
Author(s)
Komatsu N, Yutani S, Yamada A, Shichijo S, Yoshida K, Itou M, Kuromatsu R, Ide T, Tanaka M, Sata M, Itoh K.
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Journal Title
Exp Ther Med. 1(4)
Pages: 619-626
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[Journal Article] A phase II study of personalized peptide vaccination combined with gemcitabine for non-resectable pancreatic cancer patients.2010
Author(s)
Yanagimoto H, Shiomi H, Satoi S, Mine T, Toyokawa H, Yamamoto T, Tani T, Yamada A, Kwon A, Komatsu N, Itoh K, Noguchi M.
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Journal Title
Oncol Rep. 24(3)
Pages: 795-801
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[Journal Article] A phase I study of personalized peptide vaccination for advanced urothelial carcinoma patients who failed treatment with methotrexate, vinblastine, adriamycin and cisplatin.2010
Author(s)
Matsumoto K, Noguchi M, Satoh T, Tabata KI, Fujita T, Iwamura M, Yamada A, Komatsu N, Baba S, Itoh K.
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Journal Title
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[Journal Article] Phase I clinical study of a peptide vaccination for hepatitis C virus-infected patients with different HLA-class I-A alleles.2009
Author(s)
Yutani S, Komatsu N, Shichijo S, Yoshida K, Takedatsu H, Itou M, Kuromatu R, Ide T, Tanaka M, Sata M, Yamada A, Itoh K.
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Journal Title
Cancer Science 100(10)
Pages: 1935-42
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[Journal Article] Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxel.2009
Author(s)
Azuma K, Sasada T, Kawahara A, Takamori S, Hattori S, Ikeda J, Itoh K, Yamada A, Kage M, Kuwano M, Aizawa H.
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Journal Title
Lung Cancer. 64(3)
Pages: 326-33
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[Journal Article] Dexamethasone did not suppress immune boosting by personalized peptide vaccination for advanced prostate cancer patients.2008
Author(s)
Naito M, Itoh K, Komatsu N, Yamashita Y, Shirakusa T, Yamada A, Moriya F, Ayatuka H, Mohamed ER, Matsuoka K, Noguchi M.
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Journal Title
Prostate 68
Pages: 1753-1762
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[Remarks] ホームページ等
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