2010 Fiscal Year Final Research Report
Study on circadian changes in autonomic function in heart failure and central hypercapnic chemosensitivity
| Project/Area Number |
20590817
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
INOUE Hiroshi University of Toyama, 大学院・医学薬学研究部(医学), 教授 (60151619)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIRAI Tadakazu 富山大学, 大学院・医学薬学研究部(医学), 助教 (10303215)
JOHO Shuji 富山大学, 大学病院, 助教 (90334721)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 心不全 / 交感神経活動 / 概日リズム |
|---|
| Research Abstract |
This study was designed to determine abnormal circadian variations in autonomic function in rats with heart failure. We developed an experimental system that enables continuous 24-48 hour sampling of blood pressure and heart rate in conscious, unrestrained rats. Low frequency components of diastolic blood pressure variability, an index of sympathetic tone, were higher during the awakening period than during the sleeping period. The enhanced sympathetic tone during the awakening period was related to an augmentation of central chemosensitiviy evaluated by hourly intermittent hypercapnic conditions.
|
