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2010 Fiscal Year Final Research Report

Study on circadian changes in autonomic function in heart failure and central hypercapnic chemosensitivity

Research Project

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Project/Area Number 20590817
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionUniversity of Toyama

Principal Investigator

INOUE Hiroshi  University of Toyama, 大学院・医学薬学研究部(医学), 教授 (60151619)

Co-Investigator(Kenkyū-buntansha) HIRAI Tadakazu  富山大学, 大学院・医学薬学研究部(医学), 助教 (10303215)
JOHO Shuji  富山大学, 大学病院, 助教 (90334721)
Project Period (FY) 2008 – 2010
Keywords心不全 / 交感神経活動 / 概日リズム
Research Abstract

This study was designed to determine abnormal circadian variations in autonomic function in rats with heart failure. We developed an experimental system that enables continuous 24-48 hour sampling of blood pressure and heart rate in conscious, unrestrained rats. Low frequency components of diastolic blood pressure variability, an index of sympathetic tone, were higher during the awakening period than during the sleeping period. The enhanced sympathetic tone during the awakening period was related to an augmentation of central chemosensitiviy evaluated by hourly intermittent hypercapnic conditions.

  • Research Products

    (20 results)

All 2011 2010 2009 2008 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (8 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Circadian changes in autonomic function in conscious rats with heart failure : Effects of amiodarone on sympathetic surge.2011

    • Author(s)
      Ohori T, Hirai T, Joho S, Kameyama T, Nozawa T, Asanoi H, Inoue H.
    • Journal Title

      Auton Neurosci. 159

      Pages: 20-25

    • Peer Reviewed
  • [Journal Article] Transient hypercapnic stress causes exaggerated and prolonged elevation of cardiac and renal interstitial norepinephrine levels in conscious hypertensive rats.2010

    • Author(s)
      Sobajima M, Nozawa T, Nakadate T, Shida T, Ohori T, Suzuki T, Matsuki A, Hirai T, Inoue H.
    • Journal Title

      Am J Physiol (Heart Circ) in press

    • Peer Reviewed
  • [Journal Article] Renal insufficiency coexisting with heart failure is related to elevated sympathetic nerve activity.2010

    • Author(s)
      Oda Y, Joho S, Harada D, Hirai T, Asanoi H, Inoue H.
    • Journal Title

      Auton Neurosci. 155

      Pages: 104-108

    • Peer Reviewed
  • [Journal Article] Impact of sleeping position on central sleep apnea/Cheyne-Stokes respiration in patients with heart failure.2010

    • Author(s)
      Joho S, Oda Y, Hirai T, Inoue H.
    • Journal Title

      Sleep Med. 11

      Pages: 143-148

    • Peer Reviewed
  • [Journal Article] Fluvastatin attenuates diabetes-induced cardiac sympathetic neuropathy in association with a decrease in oxidative stress.2010

    • Author(s)
      Matsuki A, Nozawa T, Igarashi N, Sobajima M, Ohori T, Suzuki T, Fujii N, Igawa A, Inoue H.
    • Journal Title

      Circ J. 74

      Pages: 468-475

    • Peer Reviewed
  • [Journal Article] Atorvastatin-induced changes in plasma coenzyme q10 and brain natriuretic peptide in patients with coronary artery disease.2008

    • Author(s)
      Suzuki T, Nozawa T, Sobajima M, Igarashi N, Matsuki A, Fujii N, Inoue H.
    • Journal Title

      Int Heart J. 49

      Pages: 423-433

    • Peer Reviewed
  • [Presentation] Periodic breathing during asleep and exercise in patients with heart failure.2011

    • Author(s)
      Oda Y, Joho S, Ushijima R, Harada D, Hirai T, Inoue H.
    • Organizer
      American Heart Association Scientific Sessions.
    • Place of Presentation
      Chicago.
    • Year and Date
      2011-11-15
  • [Presentation] Relative deficiency of endogenous erythropoietin and increased muscle sympathetic nerve activity in patients with cardio-renal anemia syndrome.2010

    • Author(s)
      Joho S, Harada D, Oda Y, Hirai T, Asanoi H, Inoue H
    • Organizer
      American College of Cardiology Annual Scientific Session.
    • Place of Presentation
      Atlanta.
    • Year and Date
      20100314-20100316
  • [Presentation] Effects of bisoprolol on sympathetic morning surge in rats with chronic heart failure.2010

    • Author(s)
      Ohori T, Hirai T, Joho S, Kameyama T, Nozawa T, Asanoi H, Inoue H.
    • Organizer
      第14回日本心不全学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-08
  • [Presentation] Which parameters of sleep study were related to heart failure severity, ventilatory inefficiency or sympathetic overactivation in heart failure patients with moderate to severe central sleep apnea?2010

    • Author(s)
      Joho S, Harada D, Oda Y, Hirai T, Inoue H.
    • Organizer
      European Society of Cardiology Congress.
    • Place of Presentation
      Stockholm.
    • Year and Date
      2010-08-29
  • [Presentation] 中枢性無呼吸を有する心不全患者に対するポジションセラピーの可能性2009

    • Author(s)
      城宝秀司, 織田慶孝, 原田大輔, 平井忠和, 井上博
    • Organizer
      第57回日本心臓病学術集会
    • Place of Presentation
      札幌
    • Year and Date
      20090918-20090920
  • [Presentation] Renal insufficiency exaggerates muscle sympathetic nerve activity in patients with heart failure.2009

    • Author(s)
      Joho S, Oda Y, Harada D, Hirai T, Inoue H
    • Organizer
      American Heart Association Scientific Sessions.
    • Place of Presentation
      Orlando.
    • Year and Date
      2009-11-18
  • [Presentation] Amiodarone has an influence on hypercapnic chemosensitivity in rats with chronic heart Failure.2009

    • Author(s)
      Ohori T, Hirai T, Joho S, Kameyama T, Nozawa T, Asanoi H, Inoue H
    • Organizer
      第13回日本心不全学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-31
  • [Presentation] Sympathetic cardiorenal interaction becomes exaggerated when cardiac and renal functions are both deteriorated.2008

    • Author(s)
      Oda Y, Joho S, Hirai T, Asanoi H, Inoue H
    • Organizer
      American Heart Association Scientific Sessions.
    • Place of Presentation
      New Orleans.
    • Year and Date
      2008-11-10
  • [Book] Annual Review 2010循環器(神経調節性失神の診断・治療ガイドライン)2010

    • Author(s)
      井上博
    • Total Pages
      291-297
    • Publisher
      中外医学社
  • [Book] 重症心不全の予防と治療(貧血をなおす)2009

    • Author(s)
      城宝秀司, 井上博
    • Total Pages
      353-359
    • Publisher
      中外医学社
  • [Book] 心不全と睡眠時無呼吸症候群(睡眠時無呼吸症候群)(麻野井英次編)2008

    • Author(s)
      平井忠和
    • Total Pages
      152-158
    • Publisher
      メジカルビュー社
  • [Book] 睡眠時無呼吸症候群(精神活動・認知能力.)(麻野井英次編)2008

    • Author(s)
      城宝秀司
    • Total Pages
      200-206
    • Publisher
      メジカルビュー社
  • [Book] 原因疾患からみた心不全のアプローチ-不整脈(心不全治療Skill Upマニュアル)(北風政史編)2008

    • Author(s)
      坂本有, 井上博
    • Total Pages
      198-208
    • Publisher
      羊土社
  • [Remarks] ホームページ

    • URL

      http://kenkyu2.u-toyama.ac.jp/index.html

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Published: 2012-01-26   Modified: 2016-04-21  

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