Insights into association between autonomic nerve system and immune regulation in patients with chronic heart failure

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590821
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Shinshu University
• Principal Investigator: IZAWA Atsushi Shinshu University, 医学系研究科, 助教 (50464095)
• Project Period (FY): 2008 – 2010
• Keywords: 心臓自律神経機能 / 慢性心不全 / 動脈硬化 / リンパ球 / 免疫制御

Research Abstract

Chronic heart failure is an evolving paradigm, which limits patient's quality of life and long-term survival. In this study, we explored the association between autonomic nerve system and immune system regulating inflammatory response. The importance of iodine-123 Metaiodobenzylguanidine uptake ratio between lung and heart has been demonstrated to predict future clinical outcome in patients with idiopathic dilated cardiomyopathy. In addition, we identified an association between the decrease in regulatory T cell population and significance of atherosclerotic disease.

Research Products

• [Journal Article] 高感度CRPは血管炎症のマーカーとして使用されていますが,血栓症の発生にどのように作用しているのですか (2011)
  • Author(s): 伊澤淳, 池田宇一
  • Journal Title: 血栓と循環 (特集:血栓症に関するQ&A PART6) 19 Pages: 67-70
• [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischaemia. (2011)
  • Author(s): Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A,, Koyama J, Iwakura Y, Taki S, Ikeda U
  • Journal Title: Cardiovasc Res 90 Pages: 364-372
  • Peer Reviewed
• [Journal Article] Early Intervention With Rosuvastatin Decreases the Lipid Components of the Plaque in Acute Coronary Syndrome (2011)
  • Author(s): Otagiri K, Tsutsui H, Kumazaki S, Miyashita Y, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Koyama J, Ikeda U
  • Journal Title: Circ J 75 Pages: 633-641
  • Peer Reviewed
• [Journal Article] Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury (2011)
  • Author(s): Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U
  • Journal Title: Circulation 123 Pages: 594-614
  • Peer Reviewed
• [Journal Article] Successful Treatment of Cardiac Diffuse Large B-cell Lymphoma: A Report of Two Cases (2011)
  • Author(s): Kumazaki S, Izawa A, Minamisawa M, Ishida F, Sano K, Uehara T, Kasai H, Tomita T, Miyashita Y, Koyama J, Ikeda U
  • Journal Title: Shinshu Med J in press
  • Peer Reviewed
• [Journal Article] Elevated osteopontin levels in patients with peripheral arterial disease (2009)
  • Author(s): Koshikawa M, Aizawa K, Kasai H, Izawa A, Tomita T, Kumazaki S, Tsutsui H, Koyama J, Shimodaira S, Takahashi M, Ikeda U
  • Journal Title: Angiolog 60 Pages: 42-45
  • Peer Reviewed
• [Journal Article] Influence of circumferential pulmonary vein isolation for atrial fibrillation on ST elevation in patient with Brugada syndrome. (2009)
  • Author(s): Tomita T, Aizawa K, Shimada K, Motoki H, Otagiri K, Koshikawa M, Kasai H, Izawa A, Kumazaki S, Tsutsui H, Koyama J, Ikeda U
  • Journal Title: Int J Cardiol([電子ジャーナル])
  • Peer Reviewed
• [Journal Article] Coagulation activity is increased in the left atria of patients with paroxysmal atrial fibrillation during the non-paroxysmal period. (2009)
  • Author(s): Motoki H, Tomita T, Aizawa K, Kasai H, Izawa A, Kumazaki S, Tsutsui H, Koyama J, Ikeda U
  • Journal Title: fibrillation during the non-paroxysmal period. Comparison with chronic atrial fibro;;ation, Circ J 73 Pages: 1403-1407
  • Peer Reviewed
• [Journal Article] Noninvasive evaluation of coronary endothelial function following sirolimus-eluting stent implantation by using positron emission tomography (2009)
  • Author(s): Horigome M, Kumazaki S, Hattori N, Kasai H, Horigome M, Aizawa K, Izawa A, Tomita T, Tsutsui H, Koyama J, Sakurai S, Ikeda U
  • Journal Title: Cradiolongy 114 Pages: 157-163
  • Peer Reviewed
• [Journal Article] Rationale and design of assessment of lipophilic vs. hydrophilic statin therapy in acute myocardial infarction (the ALPS-AMI)study (2009)
  • Author(s): Kashima Y, Izawa A, Aizawa K, Koshikawa M, Kasai H, Tomita T, Kumazaki S, Tsutsui H, Koyama J, Ikeda U
  • Journal Title: J Cardiol 54 Pages: 76-79
  • Peer Reviewed
• [Journal Article] Therapeutic neovascularization by the implantation of autologous mononuclear cells in patients with connective tissue diseases (2009)
  • Author(s): Takahashi M, Izawa A, Ishigatsubo Y, Fujimoto K, Miyamoto M, Horie T, Aizawa Y, Amano J, Minota S, Murohara T, Matsubara H, Ikeda U
  • Journal Title: Curr Pharm Des 15 Pages: 2778-2783
  • Peer Reviewed
• [Journal Article] 動脈硬化とバイオマーカー(特集:潜在性動脈硬化症) (2009)
  • Author(s): 伊澤淳, 池田宇一
  • Journal Title: 動脈硬化予防 7 Pages: 53-58
• [Journal Article] M, Higuchi M, Koh CS, Yamamoto K, Immunoadsorption therapy for patients with dilated cardiomyopathy and heart failure (2008)
  • Author(s): Ikeda U, Kasai H, Izawa A, Koyama J, Yazaki Y, Takahashi M, Higuchi M, Koh CS, Yamamoto K
  • Journal Title: Curr Cardiol Rev 4 Pages: 219-222
  • Peer Reviewed
• [Journal Article] Risk stratification assessed by combined lung and heart iodine-123 metaiodobenzylguanidine uptake in patients with idiopathic dilated cardiomyopathy (2008)
  • Author(s): Kamiyoshi Y, Yazaki Y, Urushibata K, Koizumu T, Kasai H, Izawa A, Kinoshita O, Hongo M, Ikeda U
  • Journal Title: Am J Cardiol 101 Pages: 1482-1486
  • Peer Reviewed
• [Journal Article] 心筋細胞障害により拡大した心臓を小さくするためにどのような薬物療法を行うのでしょうか (2008)
  • Author(s): 伊澤淳
  • Journal Title: 薬局(特集:心不全) 59 Pages: 38-42
• [Presentation] Peak systolic velocity of pulmonary venous flow is closely associated with left ventricular global longitudinal speckle strain in patients with cardiomyopathy. (2010)
  • Author(s): Koyama J, Motoki H, Aizawa K, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Ikeda U
  • Organizer: AHA scientific sessions
  • Place of Presentation: シカゴ, 米国
  • Year and Date: 20101114-20101116
• [Presentation] Torsion Analysis in the Early Detection of Anthracycline Mediated Cardiomyopathy. (2010)
  • Author(s): Motoki H, Koyama J, Aso S, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Ikeda U
  • Organizer: AHA scientific sessions 2010
  • Place of Presentation: シカゴ, 米国
  • Year and Date: 20101114-20101116
• [Presentation] Critical Role of Hyaluronan Derived From Vascular Smooth Muscle Cells in Neointimal Formation After Vascular Injury. (2010)
  • Author(s): Takahashi M, Hata T, Kawaguchi K, Izawa A, Ikeda U
  • Organizer: AHA scientific sessions 2010
  • Place of Presentation: シカゴ, 米国
  • Year and Date: 20101114-20101116
• [Presentation] Therapeutic Angiogenesis for Patients with Ischemic Vasculitis by Autologous Mononuclear Cell Implantation. (2010)
  • Author(s): Izawa A, Ishigatsubo Y, Fujimoto K, Miyamoto M, Minota S, Horie T, Aizawa Y, Amano J, Murohara T, Matsubara H, Takahashi M, Ikeda U
  • Organizer: AHA scientific sessions 2010
  • Place of Presentation: シカゴ, 米国
  • Year and Date: 20101114-20101116
• [Presentation] 拡張型心筋症に対する免疫吸着療法における酸化ストレスへの急性期効果 (2010)
  • Author(s): 笠井宏樹, 伊澤淳, 嘉嶋勇一郎, 小山潤, 矢崎善一, 池田宇一
  • Organizer: 第14回日本心不全が学会
  • Place of Presentation: 東京
  • Year and Date: 20101007-20101009
• [Presentation] Immunoadsorption therapy may improve cardiac sympathetic nerve activity in patients with dilated cardiomyopathy (2010)
  • Author(s): Kasai H, Izawa A, Kashima Y, Aizawa K, Koshikawa M, Miyashita Y, Kumazaki S, Tomita T, Koyama J, Yazaki Y, Ikeda U
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
  • Year and Date: 20100305-20100307
• [Presentation] Improvement of longitudinal left ventricular function is associated with left atrial strain enhancement early after pulmonary-veinisolation for atrial fibrillation. (2010)
  • Author(s): Koyama J, Motoki H, Yoneyama A, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Ikeda U.
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
  • Year and Date: 20100305-20100307
• [Presentation] Effect of atrial fibrillation on left ventricular longitudinal function: serial observation by speckle tracking echocardiography. (2010)
  • Author(s): Koyama J, Motoki H, Yoneyama A, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Ikeda U.
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
  • Year and Date: 20100305-20100307
• [Presentation] Acute effect of pulmonary-vein isolation for atrial fibrillation on longitudinal left ventricular function and stroke volume. (2010)
  • Author(s): Koyama J, Motoki H, Yoneyama A, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Ikeda U.
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
  • Year and Date: 20100305-20100307
• [Presentation] Critical role of hyaluronan derived from vascular smooth muscle cells in neointimal formation after vascular injury. (2010)
  • Author(s): Kashima Y, Takahashi M, Hata T, Kawaguchi M, Izawa A, Itano N, Taniguchi S, Ikeda U
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
  • Year and Date: 20100305-20100307
• [Presentation] Contribution of CD4+-Th17 cells to angiogenesis fllowing hindlimb ischemia in mice. (2010)
  • Author(s): Hata T, Takahashi M, Kawaguchi M, Kashima Y, Hida S, Izawa A, Taki S, Iwakura Y, Ikeda U.
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
  • Year and Date: 20100305-20100307
• [Presentation] 重症慢性心不全に対する免疫吸着療法-酸化ストレスとの関連 (2009)
  • Author(s): 笠井宏樹, 嘉嶋勇一郎, 元木博彦,伊澤淳, 小山潤, 上條祐司, 樋口誠, 矢崎善一, 池田宇一
  • Organizer: 第30回日本アフェレシス学会
  • Place of Presentation: 札幌
  • Year and Date: 20090910-20090912
• [Presentation] Role of interleukin-6 and its crosstalk with AT1R in acute and chronic rejection of murine cardiac allografts, Circulation, 118, Suppl II: S1015, 2008 (2008)
  • Author(s): Izawa A, Takahashi M, Ise H, Morimoto H, Yajima N, Tagawa Y, Iwakura Y, Ikeda U.
  • Organizer: American Heart Association
  • Place of Presentation: ニューオリンズ, 米国
  • Year and Date: 20081112-20081200
• [Presentation] Sekiguchi M. Influence of recent advances in the management of heart failure and ventricular arrhythmias on survival in patients with cardiac sarcoidosis.Circulation, 118, Suppl II (2008)
  • Author(s): Yazaki Y, Horigome M, Aizawa K, Tomita T, Kasai H, Izawa A, Hongo M, Ikeda U
  • Organizer: S1033, 2008, American Heart Association
  • Place of Presentation: ニューオリンズ, 米国
  • Year and Date: 20081112-20081200
• [Presentation] Transient pseudorestrictive pattern of transmitral Doppler flow pattern in patients with paroxysmal atrial fibrillation, Circulation, 118, Suppl II: (2008)
  • Author(s): Motoki H, Koyama J, Tomita T, Aizawa K, Kasai H, Izawa A, Kumazaki S, Tsutsui H, Ikeda U
  • Organizer: S603, 2008, American Heart Association
  • Place of Presentation: ニューオリンズ, 米国
  • Year and Date: 20081112-20081200
• [Book] 心筋梗塞の再発予防.循環器疾患最新の治療 (2011)
  • Author(s): 伊澤淳, 池田宇一
  • Total Pages: 126-128
  • Publisher: 南江堂
• [Book] 実験医学2010(Buerger病および膠原病に合併する虚血肢を対象とした血管再生療法) (2010)
  • Total Pages: 165-170,2861-2866
  • Publisher: 羊土社
• [Book] 脱水 浮腫 病気と薬パーフェクトBOOK 2010,薬局増刊号 (2010)
  • Author(s): 伊澤淳
  • Total Pages: 125-130
  • Publisher: 南山堂
• [Book] コレステロールと末梢動脈硬化 コレステロール-基礎から臨床ヘ- (2009)
  • Author(s): 伊澤淳, 池田宇一
  • Publisher: ライフサイエンス出版