2011 Fiscal Year Final Research Report
Longitudinal investigation into etiologies and mechanisms of disease progression in cardiomyopathies
| Project/Area Number |
20590827
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
DOI Yoshinori 高知大学, 教育研究部・医療学系, 教授 (90140144)
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| Co-Investigator(Kenkyū-buntansha) |
KITAOKA Hiroaki 高知大学, 教育研究部・医療学系, 准教授 (10274375)
MATSUMURA Yoshihisa 高知大学, 教育研究部・医療学系, 講師 (10274391)
KUBO Toru 高知大学, 教育研究部・医療学系, 助教 (80325422)
OKAWA Makoto 高知大学, 教育研究部・医療学系, 助教 (60380341)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 心筋症 / 遺伝子 / 臨床 / 予後 |
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| Research Abstract |
We investigated the genotype-phenotype correlations in cardiomyopathies from the longitudinal point of view. In genetic analysis, we reported some mutations associated with hypertrophic cardiomyopathy(HCM), particularly mutations in cardiac myosin-binding protein C gene. In the studies of clinical phenotype in cardiomyopathies, we focused on the left ventricular remodeling of HCM and dilated cardiomyopathy, and reported several results including the usefulness of echocardiographic data and biomarkers for predicting the prognosis.
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[Journal Article] Genetic screening and doublemutation in Japanese patients with hypertrophic cardiomyopathy2011
Author(s)
Kubo T, Kitaoka H, Okawa M, Baba Y, Hirota T, Hayato K, Yamasaki N, Matsumura Y, Otsuka H, Ariura A, Doi YL
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Journal Title
Circ J
Volume: 76
Pages: 2654-2659
Peer Reviewed
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[Journal Article] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy2011
Author(s)
Kubo T, Kitaoka H, Okawa M, Yamanaka S, Hirota T, Baba Y, Hayato K, Yamasaki N, Matsumura Y, Yasuda N, Sugiura T, Doi YL
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Journal Title
Circ J
Volume: 75
Pages: 919-926
Peer Reviewed
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[Journal Article] Clinical features of dilated phase of hypertrophic cardiomyopathy in comparison with those of dilated cardiomyopathy2010
Author(s)
Hamada T, Kubo T, Kitaoka H, Hirota T, Hoshikawa E, Hayato K, Shimizu Y, Okawa M, Yamasaki N, Matsumura Y, Yabe T, Takata J, Doi YL
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Journal Title
Clinical Cardiology
Volume: 33
Pages: E24-E28
Peer Reviewed
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[Journal Article] Serum cardiac troponin I is related to increased left ventricular wall thickness2010
Author(s)
Kubo T, Kitaoka H, Okawa M, Yamanaka S, Hirota T, Hoshikawa E, Hayato K, Yamasaki N, Matsumura Y, Yasuda N, Sugiura T, Doi YL
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Journal Title
left ventricular dysfunction, and male gender in hypertrophy cardiomyopathy
Volume: 33
Pages: E1-E7
Peer Reviewed
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[Journal Article] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype : Comparison of pure-apical form and distal-dominant form2009
Author(s)
Kubo T, Kitaoka H, Okawa M, Hirota T, Hoshikawa E, Hayato K, Yamasaki N, Matsumura Y, Yabe T, Nishinaga M, Takata J, Doi YL
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Journal Title
Circ J
Volume: 73
Pages: 2330-2336
Peer Reviewed
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[Journal Article] Improvement in prognosis of dilated cardiomyopathy in the elderly over the past 20 years2008
Author(s)
Kubo T, Matsumura Y, Kitaoka H, Okawa M, Hirota T, Hamada T, Hitomi N, Hoshikawa E, Hayato K, Shimizu Y, Yamasaki N, Yabe T, Nishinaga M, Takata J, Doi Y
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Journal Title
J Cardiol
Volume: 52
Pages: 111-117
Peer Reviewed
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[Journal Article] Hypertrophic cardiomyopathy with mild left ventricular remodeling : echocardiographic assessment usingleft ventricular wall motion score2008
Author(s)
Hayato K, Okawa M, Matsumura Y, Kitaoka H, Kubo T, Hitomi N, Yamasaki N, Yabe T, Furuno T, Takata J, Nishinaga M, Doi YL
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Journal Title
J Cardiol
Volume: 51
Pages: 95-105
Peer Reviewed
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