2010 Fiscal Year Final Research Report
Role of mast cells in the development of abdominal aortic aneurysm
| Project/Area Number |
20590830
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
TSURUDA Toshihiro University of Miyazaki, 医学部, 助教 (10389570)
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| Co-Investigator(Kenkyū-buntansha) |
ASADA Yujiro 宮崎大学, 医学部, 教授 (70202588)
HATAKEYAMA Kinta 宮崎大学, 医学部, 講師 (60325735)
KITAMURA Kazuo 宮崎大学, 医学部, 教授 (50204912)
KATO Johji 宮崎大学, フロンティア学実験総合センター, 教授 (20274780)
ONITSUKA Toshio 宮崎大学, 医学部, 教授 (60108595)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 臨床心血管病態学 |
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| Research Abstract |
Main purpose of the research was aimed at better understanding the pathophysiology of abdominal aortic aneurysm (AAA), and at pursuing a potential medical therapy for the disorder. We specifically focused on the adventitial layer on the pathogenesis. The number of "mast cells" was found to increase in the outer media or adventitia of human AAA. Aneurysmal dilatation of the aorta was seen in the control rats following peri-aortic application of calcium chloride (CaCl_2) treatment, but not in the mast cell-deficient rats. The tranilast, an inhibitor of mast cell degranulation, attenuated AAA development in the rodent models. In the cell culture experiment, a mast cell directly augmented MMP-9 activity. These data suggest that adventitial mast cells play a critical role in the progression of AAA. In addition, inhibition of mast cell activity might be a potential therapeutic target for attenuating the development/progression of AAA.
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[Journal Article] Adventitial macells contribute to pathogenesis in tprogression of abdominal aortic aneurysm.2008
Author(s)
Tsuruda T, Kato J, Hatakeyama K, Kojima K, Yano M, Yano Y, Nakamura K, Nakamura-Uchiyama F, Matsushima Y, Imamura T, Onitsuka T, Asada Y, Nawa Y, Eto T, Kitamura K.
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Journal Title
Circ Res. 102
Pages: 1368-1377
Peer Reviewed
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[Presentation] Increased glycolysis activity in macrophages contributes to the progression of abdominal aortic aneurysm.2010
Author(s)
Tsuruda T, Nagamachi S, Sekita Y, Sakamoto S, Hatakeyama K, Imamura T, Asada Y, Onitsuka T, Kitamura K.
Organizer
American Heart Association. Scientific Sessions 2010.
Place of Presentation
Chicago, IL, USA
Year and Date
20101113-20101117
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[Presentation] Increased glucose metabolic activity in abdominal aortic aneurysm : relation to facilitative glucose transporters and matrix metalloproteinases.2010
Author(s)
Tsuruda T, Nagamachi S, Endo G, Nishimura M, Matsuyama M, Hatakeyama K, Onistuka T, Imamura T, Asada Y, Kitamura K.
Organizer
European Society of Cardiology Congress 2010.
Place of Presentation
Stockholm, Sweden
Year and Date
20100828-20100901
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