2010 Fiscal Year Final Research Report
The pathophysiological role of aldosterone in cardiovascular disease.
| Project/Area Number |
20590841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
YOSHIMURA Michihiro Jikei University School of Medicine, 医学部, 教授 (30264295)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 心血管内分泌 / アルドステロン / 酸化ストレス / カルシウムチャンネル |
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| Research Abstract |
Alodosterone plays a key role in the pathogenesis of heart failure. In addition to the classical adrenocortical aldosterone synthesis pathway, we have previously reported that aldosterone is also produced in the heart. In this study, we demonstrated that N-type Calcium channel which has been indentified exclusively in sympathetic nerve terminals actually regulates aldosterone production in adrenal grands. Moreover, we found that aldosterone production in the heart is deeply affected by glucose and/or sodium condition. These results further elucidate the contribution of sodium and glucose condition to the pathophysiological significance in the cardiovascular diseases, and will lead to the development of novel therapeutic approach in the future.
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[Journal Article] Clinical Factors affecting Serum Potassium Concentration in Cardio-renal Decompensation Syndrome2010
Author(s)
Ueno H, Yoshimura M, Nakayama M, Yamamuro M, Nishijima T, Kusuhara K, Nagayoshi Y, Kojima S, Kaikita K, Sumida H, Sugiyama S, Ogawa H
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Journal Title
Int J Cardiol 138(2)
Pages: 174-181
Peer Reviewed
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[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats.2009
Author(s)
Kawai M, Hongo K, Komukai K, Morimoto S, Nagai M, Seki S, Taniguchi I, Mochizuki S, Yoshimura M
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Journal Title
Hypertens Res 32(7)
Pages: 604-610
Peer Reviewed
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[Journal Article] Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocyocytes.2008
Author(s)
Yamamuro M, Yoshimura M, Nakayama M, Abe K, Sumida H, Sugiyama S, Saito Y, Nakao K, Yasue H, Ogawa H
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Journal Title
Circ J 72(8)
Pages: 1346-1350
Peer Reviewed
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