Investigation of the mechanisms of myocardial protection afforded by ischemic preconditioning in human

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590842
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Nippon Medical School
• Principal Investigator: TAKANO Hitoshi Nippon Medical School, 医学部, 講師 (90277533)
• Co-Investigator(Kenkyū-buntansha): YASUTAKE Masahiro 日本医科大学, 医学部, 准教授 (70281433)
• Project Period (FY): 2008 – 2010
• Keywords: 虚血再灌流傷害 / 心筋保護 / 活性酸素種 / 肥満遺伝子

Research Abstract

Ischemic preconditioning (PC) is the phenomenon whereby brief episodes of ischemia render the heart more resistant to the subsequent ischemia. To determine the mechanisms of PC in human, we sought the differences between the PC positive group and the PC negative group during percutaneous coronary intervention. We found the following findings. 1) The marker reflecting reactive oxygen species injury increased in coronary sinus after the brief myocardial ischemia only in the PC positive group, but not in the PC negative group. 2) Patients with obesity related-genes abnormality were more frequent in PC negative group. Thus, reactive oxygen species and a factor related with obesity related-gene abnormality may involve the mechanisms of PC in human.

Research Products

• [Journal Article] SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population. (2011)
  • Author(s): Aoki A, Ozaki K, Takano H, Yasutake M, Tanaka T
  • Journal Title: J Hum Genet. 56巻 Pages: 47-51
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Kiriyama T, Fukushima Y, Takano H, Mizuno K, Kumita
  • Journal Title: SI.Circ.J.
  • Peer Reviewed
• [Journal Article] Optical coherence tomography after new scoring balloon angioplasty for in-stent restenosis and de novo coronary lesions. (2010)
  • Author(s): Takano M, Takano H, Yasutake M, Mizuno K
  • Journal Title: Int J Cardiol. 141巻 Pages: 51-53
  • Peer Reviewed
• [Presentation] Possible Role of Reactive Oxygen Species during the Development of Ischemic Preconditioning in Patients Undergoing Percutaneous Coronary Intervention. (2010)
  • Author(s): Takano H, Kusama Y, Yamamoto E, Yasutake M, Mizuno K
  • Organizer: International Society for Heart Research
  • Year and Date: 20100000
• [Presentation] Low dose aspirin may ameliorate long term clinical outcome in patients with coronary spastic angina. (2010)
  • Author(s): Takano H, Yamamoto E, Takagi G, Aoki S, Asai K, Yasutake M, Mizuno K
  • Organizer: American College of Cardiology 59th Annual Scientific Session.
  • Year and Date: 20100000
• [Presentation] Economical benefit of the prevention of contrast-induced nephropathy in patients with chronic kidney disease. (2009)
  • Author(s): Takano H, Yamamoto E, Takano M, Takagi G, Asai K, Yasutake M, Mizuno K
  • Organizer: European Society of Cardiology
  • Year and Date: 20090000
• [Book] 薬剤性消化管傷害 (2009)
  • Author(s): 坂本長逸,高野仁司, 他
  • Total Pages: 122