2010 Fiscal Year Final Research Report
Investigation on Multi-biomarker Strategy by novel coronary imagings
| Project/Area Number |
20590843
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SEINO Yoshihiko Nippon Medical School, 医学部, 教授 (10163073)
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| Co-Investigator(Renkei-kenkyūsha) |
IBUKI Chikao 日本医科大学, 医学部, 講師 (80193639)
TAKANO Masamichi 日本医科大学, 医学部, 講師 (40287719)
OHBA Takayoshi 日本医科大学, 医学部, 助教 (00516015)
MURAKAMI Daisuke 日本医科大学, 医学部, 助教 (70445782)
YAMAMOTO Masanori 日本医科大学, 医学部, 助教 (90449265)
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| Project Period (FY) |
2008 – 2010
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| Keywords | Optical coherence tomography / vulnerable plaque / biomarker / high sensitivity troponin T / NT-proBNP / sLOX-1 / MMP-9 |
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| Research Abstract |
The present investigation for the development of multi-biomarker strategy in coronary artery disease revealed importance of the detail analyses concerning the plaque tissue and fibrous cap components by the combination of novel coronary imaging (coronary angioscope, intravascular ultrasound, and optical coherence tomography) and cardiovascular biomarkers. Sequential observation in novel coronary imaging following the coronary stent implantation (BMS versus DES) demonstrated marked differences in the neointimal formation between BMS and DES, especially the development of neovascular microchannels in DES restenosis site, which should suggest the necessity of the development of further new marker reflecting neovascular formation. As the novel biomarker for the most upstream of plaque vulnerability, the present investigation demonstrated usefulness of the combination of sLOX-1, MMP-9, MPO,high-sensitivity troponin T and NT-proBNP. These assessment and OCT analysis revealed high prevalence of high-risk plaque for peri-procedural myocardial injury following percutaneous coronary intervention even in patients with stable coronary artery disease, which was mostly characterized by larger angle of lipid plaque and thinner fibrous cap at the culprit lesion by OCT, namely, silent vulnerable plaque or the upstream vulnerable plaque.
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Research Products
(29 results)
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[Journal Article] Late vascular responses from 2 to4 years after implantation of sirolimus-eluting stents : Serial observations by intracoronary optical coherence tomography2011
Author(s)
Takano M, Yamamoto M, Mizuno M, Murakami D, Inami T, Kimata N, Murai K, Kobayashi N, Okamatsu K, Seino Y, Mizuno K
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Journal Title
Circulation Cardiovascular Interventions 3(5)
Pages: 476-489
Peer Reviewed
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[Journal Article] Elevation of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels After Plaque Disruption2009
Author(s)
Yamamoto M, Seino Y, Okamatsu K, Inami T, Murakami D, Ohba T, Aoki S, Ibuki C, Takano M, Mizuno K, Hata N
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Journal Title
Circulation 120
Pages: S975
Peer Reviewed
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[Presentation] Elevation of soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels After Plaque Disruption2009
Author(s)
Yamamoto M, Seino Y, Okamatsu K, Inami T, Murakami D, Ohba T, Aoki S, Ibuki C, Takano M, Mizuno K, Hata N
Organizer
American Heart Association Scientific Session 2009
Place of Presentation
米国, Orlando
Year and Date
2009-11-17
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[Presentation] Link of Sleep Apnea Syndrome to Coronary Atherosclerotic Burden and Elevated Cardiac Biomarkers in Stable Coronary Artery Disease Patients2009
Author(s)
Inami T, Seino Y, Yamamoto M, Kimata N, Murakami D, Takano M, Ohba T, Aoki S, Ibuki C, Mizuno K
Organizer
American Heart Association Scientific Session 2009
Place of Presentation
米国, Orlando
Year and Date
2009-11-17
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[Presentation] Even Mild Elevation of sLOX-1 may Reflect Coronary Atherose- clerotic Plaque Burden in Non-AMI Coronary Artery Disease Patients2009
Author(s)
Inami T, Yamamoto M, Kimata N, Okada K, Tara S, Murakami D, Tajika K, Ohba T, Aoki S, Ibuki C, Yohoyama S, Hata N, Takano M, Seino Y
Organizer
第73回日本循環器学会
Place of Presentation
大阪国際会議場
Year and Date
2009-03-21
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