2010 Fiscal Year Final Research Report
Diagnosis of unstable angina pectoris by serum deoxyribonuclease I as a new diagnostic maker of myocardial ischemia
| Project/Area Number |
20590845
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YASUDA Toshihiro 福井大学, 医学部, 教授 (80175645)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 心臓病態学 |
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| Research Abstract |
In this study, a high diagnostic efficacy of serum deoxyribonuclease I(DNase I) activity levels could be observed in the early phase, even in unstable angina/non ST segment elevation myocardial infarction(UAP/NSTEMI) patients who did not show elevated levels of conventional cardiac markers, such as troponin T or creatine kinase-MB. The serum DNase I can be a useful marker for the early diagnosis of UAP/NSTEMI after the onset of chest pain, irrespective of the evidence of myocardial injury.
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