2010 Fiscal Year Final Research Report
A role of CX3CL1/CX3CR1 in atherosclerosis
| Project/Area Number |
20590850
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
TANAKA Seiya University of Occupational and Environmental Health, Japan, 医学部, 非常勤医師 (80352300)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SONODA Shinjou 産業医科大学, 医学部, 助教 (90299610)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 冠動脈疾患 / PCI / ケモカイン / 再狭窄 / プラーク破裂 |
|---|
| Research Abstract |
The cause of rupture of atherosclerotic site in vasculature, which trigger unstable angina and myocardial infarction, is not elucidated yet. In this research we found that CX3CL1, one of protein which induce inflammation, was elevated immediately after injuring atherosclerotic site and maintained the level at least 12-hour. And it was more elevated with more lipid-rich atherosclerotic site. It is suggested that plasma CX3CL1 might be a diagnostic marker of unstable angina and myocardial infarction.
|
Research Products
(2 results)
