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2010 Fiscal Year Final Research Report

Vagal Nerve Stimulation : A Novel Therapeutic Strategy for Dilated Cardiomyopathy

Research Project

  • PDF
Project/Area Number 20590853
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKochi University

Principal Investigator

ZHENG Can  Kochi University, 教育研究部・医療学系, 助教 (50443495)

Co-Investigator(Renkei-kenkyūsha) LI Meihua  国立循環器病センター(研究所), 循環動態機能部, 特任研究員 (60443496)
KAWADA Toru  国立循環器病センター(研究所), 循環動態機能部, 室長 (30243752)
Project Period (FY) 2008 – 2010
Keywords迷走神経刺激 / 特発拡張型心筋症 / 自己免疫
Research Abstract

Myocarditis is an inflammatory heart disease, considered as one of the main causes of dilated cardiomyopathy, a fatal heart disease. Current therapeutic strategy is focus on the anti-inflammatory and nosotropic treatments by pharmaceutics. In this study, we hypothesis and verified that vagal nerve stimulation may exert beneficial effects on cardiac inflammation and demonstrated that vagal stimulation attenuates ventricle remodeling and improve survival after myocardial infarction, which may be associated with suppression of acute inflammatory reactions.

  • Research Products

    (12 results)

All 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (8 results)

  • [Journal Article] Open-loop dynamic and static characteristics of the carotid sinus baroreflex in rats with chronic heart failure after myocardial infarction.2010

    • Author(s)
      Kawada T, Li M, Kamiya A, Shimizu S, Uemura K, Yamamoto H, Sugimachi M.
    • Journal Title

      J Physiol Sci. 60(4)

      Pages: 283-298

    • Peer Reviewed
  • [Journal Article] Early Short-Term Vagal Nerve Stimulation Attenuates Cardiac Remodeling After Reperfused Myocardial Infarction.2010

    • Author(s)
      Uemura K, Zheng C, Li M, Kawada T, Sugimachi M.
    • Journal Title

      J Card Fail. 16(8)

      Pages: 689-99

    • Peer Reviewed
  • [Journal Article] Effect of the cholinesterase inhibitor donepezil on cardiac remodeling and autonomic balance in rats with heart failure.2010

    • Author(s)
      Okazaki Y, Zheng C, Li M, Sugimachi M.
    • Journal Title

      J Physiol Sci. 60(1)

      Pages: 67-74

    • Peer Reviewed
  • [Journal Article] 生体情報の長期取得のための神経再生型電極の開発2008

    • Author(s)
      杉町勝, 川田徹, 鄭燦, 佐藤隆幸
    • Journal Title

      人工臓器 37

      Pages: 175-178

  • [Presentation] Vagal Stimulation Markedly Suppressed Arrhythmic Death and Prevented Cardiac Dysfunction in Rats after Acute Myocardial Infarction.2010

    • Author(s)
      李梅花
    • Organizer
      19th International Conference of the Cardiovascular System Dynamics Society.
    • Place of Presentation
      Kyushu University, Fukuoka.
    • Year and Date
      2010-09-25
  • [Presentation] A New Intelligent Technique of Fluid Restriction in Small Animals.2010

    • Author(s)
      鄭燦
    • Organizer
      第31回日本循環制御医学会総会
    • Place of Presentation
      千里ライフセンター,大阪
    • Year and Date
      2010-05-28
  • [Presentation] Donepezil Markedly Suppresses Ventricular Dysfunction and Improves Neurohumoral States on Top of Losartan in Rats with Extensive Myocardial Infarction.2009

    • Author(s)
      鄭燦
    • Organizer
      AHA Scientific Sessions 2009.
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2009-11-18
  • [Presentation] 重症心不全に対する迷走神経刺激療法2009

    • Author(s)
      宍戸稔聡、李梅花、鄭燦、上村和紀、川田徹、杉町勝
    • Organizer
      第24回生体・生理工学シンポジウム
    • Place of Presentation
      仙台市、東北大学
    • Year and Date
      2009-09-24
  • [Presentation] Blockade of α7-Nicotinic Acetylcholine Receptors Attenuates Cardio-protective Effects of Donepezil in Rats with Extensive Myocardial Infarction.2009

    • Author(s)
      Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Shishido T, Akiyama T, Sugimachi M.
    • Organizer
      第73回日本循環器学会総会・学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-28
  • [Presentation] Drinking Style of Myocardial Infarcted Rats : A Proposal for Fluid Restriction Prescription for Patients with Chronic Heart Failure.2009

    • Author(s)
      Zheng C. Li M, Kawada T, Sugimachi M, Sato T.
    • Organizer
      第73回日本循環器学会総会・学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-28
  • [Presentation] Addition of acetylcholinesterase inhibitor, donepezil improves neurohumoral states further than losartan alone in rats with extensive myocardial infarction.2009

    • Author(s)
      李梅花
    • Organizer
      第73回日本循環器学会総会・学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-28
  • [Presentation] Vagal Stimulation markedly Suppresses Arrhythmias and Improve Survival Rate of Endstage Heart Failure Rats.2008

    • Author(s)
      Zheng C, Li M, Kawada T, Sugimachi M.
    • Organizer
      第72回日本循環器学会総会・学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-29

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Published: 2012-01-26   Modified: 2016-04-21  

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