2010 Fiscal Year Final Research Report
Role of autophagy in the progression of heart failure
| Project/Area Number |
20590865
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAGUCHI Osamu Osaka University, 大学院・医学系研究科, 助教 (90467580)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 心不全 / オートファジー |
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| Research Abstract |
Constitutive autophagy is important for control of the quality of proteins and organelles to maintain cell function. We have previously reported that autophagy in the heart has a protective role in the pathogenesis of heart failure. In the present study, we monitored cardiac-specific Atg5-deficient mice. The Atg5-deficient mice began to die after the age of six months. Atg5-deficient mice exhibited severe cardiac dysfunction at the age of 10 months. Ultrastructural analysis revealed a disorganized sarcomere structure and collapsed mitochondria in Atg5-deficient mice. These results suggest that continuous constitutive autophagy plays a crucial role in maintaining cardiac structure and function.
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