2010 Fiscal Year Final Research Report
To examine the role of Epac, a new beta-adrenergic signaling molecule, for the development of heart failure
Project/Area Number |
20590871
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Yokohama City University |
Principal Investigator |
OKUMURA Satoshi Yokohama City University, 医学部, 准教授 (60233475)
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Co-Investigator(Kenkyū-buntansha) |
SATO Motohiko 横浜市立大学, 医学部, 准教授 (40292122)
KUROTANI Reiko 横浜市立大学, 医学研究科, 特任助教 (00453043)
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Project Period (FY) |
2008 – 2010
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Keywords | サイクリックAMP / シグナル伝達 / 循環器・高血圧 / 心不全 / 遺伝子改変マウス |
Research Abstract |
It is well known that sympathetic and thus catecholamine signal is activated thereafter to compensate cardiac dysfunction. The mechanism of such compensation by catecholamine has been traditionally understood as PKA-mediated enforcement of cardiac contractility. We hypothesized that Epac, a new target of cAMP signal that functions independently from PKA, also plays a key role. Epac1 inhibited the Jak-STAT pathway and iNOS protein in the heart in response via IL-6. Activation of the cAMP/Epac pathway protected the heart against cytokine-induced cardiac dysfunction, suggesting a new role of catecholamine signal in compensating cardiac dysfunction in endotoxemia.
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[Journal Article] Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGF・・signaling down-regulation.2011
Author(s)
Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagao T, Esposito D, Tayler TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, Kimura S
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Journal Title
J Biol Chem 386
Pages: 19682-19692
Peer Reviewed
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[Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010
Author(s)
Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y
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Journal Title
Circ Res 106
Pages: 1882-1892
Peer Reviewed
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[Journal Article] Caveolin gene transfer improves glucose metabolism in diabetic mice.2010
Author(s)
Otsu K, Toya Y, Oshikawa J, Kurotani R, Yazawa T, Sato M, Yokoyama U, Umemura S, Minamisawa S, Okumura S, Ishikawa Y
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Journal Title
Am J Physiol Cell Physiol 298
Pages: C442-C445
Peer Reviewed
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[Journal Article] Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight.2008
Author(s)
Okumura S, Tsunematsu T, Bai Y, Jiao Q, Ono S, Suzuki S, Kurotani R, Sato M, Umemura S, Minamisawa S, Ishikawa Y
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Journal Title
J Apply Physiol 105
Pages: 173-179
Peer Reviewed
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[Presentation] Pharmacological activation of type 5 adenylyl cyclase stabilizes heart rate under microgravity induced by parabolic flight2010
Author(s)
Satoshi Okumura, Yunzhe Bai, Takashi Tsunematsu, Meihua Jin, Qibin Jiao, Sayaka Suzuki, Reiko Kurotani, Utako Yokoyama, Motohiko, Sato, Kousaku Iwatsubo, Yoshihiro Ishikawa
Organizer
第74回日本循環器学会学術集会
Place of Presentation
京都
Year and Date
20100300
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