2010 Fiscal Year Final Research Report
Molecular Mechanisms of Hyper-contraction of Drug-eluting Stent Implanted Coronary Arteries
| Project/Area Number |
20590875
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
YASUDA Satoshi Tohoku University, 大学院・医学系研究科, 准教授 (00431578)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOKAWA Hiroaki 東北大学, 大学院・医学系研究科, 教授 (00235681)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 循環器・高血圧 / トランスレーショナルリサーチ |
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| Research Abstract |
Accumulating evidence indicates that coronary vasoconstricting responses are enhanced at the edges of coronary segment implanted with drug-eluting stents (DES) compared with bare-metal stent (BMS) in humans. We have recently demonstrated that Rho-kinase pathway plays an important role in DES-induced coronary hyperconstricting responses in pigs in vivo and in patients with coronary artery diseases. Also, chronic treatment with long-acting nifedipine suppresses DES-induced coronary hyperconstricting responses and inflammatory changes, at least in part, through Rho-kinase pathway inhibition in pigs in vivo.
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[Journal Article] Treatment with nifedipine suppresses coronary hyperconstricting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo-Possible involvement of Rho-kinase pathway-2011
Author(s)
Tsuburaya R, Yasuda S, Shiroto T, Ito Y, Gao JY, Aizawa K, Kikuchi Y, Ito K, Takahashi J, Ishibashi-Ueda H, Shimokawa H.
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Journal Title
Peer Reviewed
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[Presentation] Involvement of Rho-kinase Activation in the Pathogenesis of coronary hyperconstricting responses by drug-eluting stents in patients with coronary artery disease.2011
Author(s)
Aizawa K, Yasuda S, Takahashi J, Takii T, Kikuchi Y, Tsuburaya R, Ito Y, Ito K, Nakayama M, Takeda M, Shimokawa H.
Organizer
日本循環器学会学術集会
Place of Presentation
横浜
Year and Date
20110318-20110321
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[Presentation] Rho-kinase activity in circulating neutrophils for diagnosis and disease activity assessment of vasospastic angina.2011
Author(s)
Kikuchi Y, Aizawa K, Yasuda S, Tsuburaya R, Ito Y, Matsumoto Y, Takeda M, Nakayama M, Ito K, Takahashi J, Shimokawa H.
Organizer
日本循環器学会学術集会
Place of Presentation
横浜
Year and Date
20110318-20110321
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[Presentation] Enhanced Rho-kinase activity in circulating neutrophils in patients with vasospastic angina-Possible usefulness for diagnosis and disease activity assessment-.2010
Author(s)
Kikuchi Y, Aizawa K, Yasuda S, Tsuburaya R, Ito Y, Nakayama M, Takeda M, Ito K, Takahashi J, Shimokawa H.
Organizer
Annual Scientific Meeting of the American Heart Association;
Place of Presentation
Chicago, USA.
Year and Date
20101113-20101117
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