2010 Fiscal Year Final Research Report
Analysis of functional EPC for the treatment of ischemic disease
| Project/Area Number |
20590876
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
OHNEDA Osamu University of Tsukuba, 大学院・人間総合科学研究科, 教授 (30311872)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Toshiharu 筑波大学, 大学院・人間総合科学研究科, 助教 (50400677)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGANO Masumi 筑波大学, 大学院・人間総合科学研究科, 助教 (30436282)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 再生医学 / 循環器・高血圧 / 移植・再生医療 / 細胞・組織 |
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| Research Abstract |
We have reported previously that ALDH-Low EPC possess hypoxic response. In this study, we examined how hypoxia-inducible factor (HIF) is involved in the repair of ischemic tissue in a mouse flap model. HIF-2alpha but not HIF-1alpha was highly associated with the reduced tissue damage in ischemia. Finally, we found that HIF-target genes, VEGF and CXCR4, have an important role for the neovascularization in ischemic tissue.
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Research Products
(31 results)
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[Journal Article] Identification of human placenta-derived mesenchymal stem cells involved in re-endothelialization2010
Author(s)
Tu T, Kimura K, Nagano M, Yamashita T, Ohneda K, Sugimori H, Sato F, Sakakibara Y, Hamada H, Yoshikawa H, Son H, Ohneda O
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Journal Title
J Cell Physiol. 226
Pages: 224-235
Peer Reviewed
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[Journal Article] Abnormal heart development and lung remodeling in mice lacking a HIF-related bHLH-PAS protein NEPAS2008
Author(s)
Yamashita T, Ohneda O, Nagano M, Iemitsu M, Makino Y, Tanaka H, Miyauchi H, Goto K, Ohneda K, Fujii-Kuriyama Y, Lorenz Poellinger, Yamamoto M
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Journal Title
Mol.Cell.Biol. 28
Pages: 1285-1297
Peer Reviewed
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