2010 Fiscal Year Final Research Report
Development of new treatment for atherosclerosis by regulating cell-mediated immunity
| Project/Area Number |
20590880
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ISOBE Mitsuaki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (80176263)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Juniichi 東京医科歯科大学 (90313858)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 動脈硬化 / 心臓移植 / 冠動脈再狭窄 / 細胞性免疫 / トランスジェニックマウス |
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| Research Abstract |
We investigated the role of cell-mediated immunity on the mechanism of arterioscelrosis using mouse models of cardiac allograft transplantation and wire-induced injury of the femoral artery. We paid attention to MMP-9, ICAM-1, and adiponectin as mediators or suppressors of arteriosclerosis in these models. Clarithromycin which suppresses MMP-9 activity and siRNA ICAM-1 were effective in suppressing arterial lesions and adiponectin over expression mouse showed lesser extent of chronic allograft rejection. These results indicate the role of immunity and inflammation on the arterioscelrosis and these new agents may be useful as new targets for prevention of clinical diseases.
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Research Products
(17 results)
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[Journal Article] A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.2010
Author(s)
Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia C-p, Keene AC, Alayari NN, Elling U, Berger C, Novatchkova M, Koglgruber R, Nishina H, Isobe M, Pospisilik JA, Imai Y, Knoblich JA, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Bodmer R, Penninger JM
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Journal Title
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