2010 Fiscal Year Final Research Report
Applied Reserch of Apop protein for the treatment of Atherosclerosis
| Project/Area Number |
20590882
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
YASUDA Osamu Osaka University, 医学部附属病院, 特任准教授 (00372615)
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| Co-Investigator(Kenkyū-buntansha) |
RAKUGI Hiromi 大阪大学, 医学系研究科, 教授 (20252679)
FUKUO Keisuke 武庫川女子大学, 生活環境学部, 教授 (40156758)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 分子血管病態学 |
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| Research Abstract |
Apoptogenic Protein (Apop) was originally identified in the atherosclerotic plaques of model animals. Apop gene expression was also identified in human atherosclerosis in carotid arteries. Proliferative smooth muscle cells, which contribute to the formation of atherosclerosis, expressed Apop, while contractile smooth muscle cells in normal arteries did not. These findings indicate the implication of Apop in the development of atherosclerosis. Moreover, Apop deficient mouse was generated in this study to reveal the function of Apop gene in vivo.
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