• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Role of endothelial proteinase-activated receptors in the early phase of the development of vascular lesions.

Research Project

  • PDF
Project/Area Number 20590883
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyushu University

Principal Investigator

HIRANO Mayumi  Kyushu University, 大学院・医学研究院, 助教 (80336031)

Co-Investigator(Kenkyū-buntansha) HIRANO Katsuya  九州大学, 医学研究院, 准教授 (80291516)
Project Period (FY) 2008 – 2010
Keywords分子血管病態学
Research Abstract

The present study elucidated the role of proteinase-activated receptors(PARs) in the early phase of the development of atherosclerotic vascular lesions. Thrombin increased endothelial permeability by two distinct pathways by activating PAR1 ; one is mediated by Gα13, and independent of Ca^<2+>, but dependent of Rho kinase-mediated MLC di-phosphorylation ; other is mediated by Gαq, and independent of MLC di-phosphorylation, but dependent on Ca^<2+>.

  • Research Products

    (15 results)

All 2011 2010 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid hemorrhage.2011

    • Author(s)
      Kameda K, Kikkawa Y, Hirano M, Matsuo S, Sasaki T, Hirano K
    • Journal Title

      Br J Pharmacol (in press)

    • Peer Reviewed
  • [Journal Article] Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca^<2+>-sensitivity and induces vasoconstriction in porcine pulmonary arteries.2010

    • Author(s)
      Maki J, Hirano M, Hoka S, Kanaide H, Hirano K
    • Journal Title

      Br J Pharmacol 159

      Pages: 919-927

    • Peer Reviewed
  • [Journal Article] Up-regulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas.2010

    • Author(s)
      Aman M, Hirano M, Kanaide H, Hirano K
    • Journal Title

      J Vase Res 47

      Pages: 494-506

    • Peer Reviewed
  • [Journal Article] Impaired Feedback regulation of the receptor activity and the myofilament Ca^<2+> sensitivity contributes to increased vascular reactiveness after subarachnoid hemorrhage.2010

    • Author(s)
      Kikkawa Y, Kameda K, Hirano M, Sasaki T, Hirano K
    • Journal Title

      J Cerb Blood Flow Metab 30

      Pages: 1637-1650

    • Peer Reviewed
  • [Journal Article] Involvement of reactive oxygen species in the thrombin-induced pulmonary vasoconstriction.2010

    • Author(s)
      Maki J, Hirano M, Hoka S, Kanaide H, Hirano K
    • Journal Title

      Am J Resp Crit Care Med 182

      Pages: 1435-1444

    • Peer Reviewed
  • [Journal Article] Enhanced contractile response of the basilar artery to platelet-derived growth factor in subarachnoid hemorrhage.2009

    • Author(s)
      Maeda Y, Hirano K, Hirano M, Kikkawa Y, Kameda K, Sasaki T, Kanaide H
    • Journal Title

      Stroke 40

      Pages: 591-596

    • Peer Reviewed
  • [Journal Article] Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca^<2+> influx in vascular endothelial cells.2009

    • Author(s)
      Hirano K, Hirano M, Hanada A
    • Journal Title

      J Cell Biochem 108

      Pages: 499-507

    • Peer Reviewed
  • [Presentation] Thrombin causes barrier dysfunction via two distinct signal transduction pathways in vascular endothelial cells2011

    • Author(s)
      平野真弓、平野勝也
    • Organizer
      第84回日本薬理学会年会(誌上開催)
    • Year and Date
      2011-03-22
  • [Presentation] Differential regulation of the thrombin- induced mono- and di-phosphorylation of myosin light chain in vascular endothelial cells内皮細胞においてトロンビンが引き起こすミオシン軽鎖の1リン酸化と2リン酸化は異なる制御を受ける2010

    • Author(s)
      平野真弓、平野勝也
    • Organizer
      第83回日本薬理学会年
    • Place of Presentation
      大阪
    • Year and Date
      20100316-20100318
  • [Presentation] Involvement of two signaling pathways in the thrombin-induced barrier dysfunction in vascular endothelial cells.2010

    • Author(s)
      平野真弓、花田亜希子、平野勝也
    • Organizer
      第63回日本薬理学会西南部会(合同開催第20回日韓薬理学合同セミナー)
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-11-26
  • [Presentation] A new method for analyzing myosin light chain phosphorylation with a Phos-tag^<TM> technology.2009

    • Author(s)
      平野真弓、平野勝也
    • Organizer
      Phos-tag^<TM>技術を用いたミオシン軽鎖リン酸化の新たな定量解析法第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20090316-20090318
  • [Presentation] Phos-tag^<TM> SDS-PAGE analysis revealed differential requirement of Ca^<2+> source for the thrombin-induced mono- and di-phosphorylation of myosin light chain in vascular endothelial cells.2009

    • Author(s)
      平野真弓, 平野勝也
    • Organizer
      International symposium of smooth muscle research "Post-genomic advances in the physiology of smooth muscle", Satellite Symposium of the International Union of Physiological Society World Congress 2009
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-23
  • [Presentation] トロンビンが引き起こす血管内皮細胞のCa^<2+>流入におけるSTIM1の関与トランスポーターワークショップIN福岡2008

    • Author(s)
      平野真弓、平野勝也
    • Place of Presentation
      福岡
    • Year and Date
      2008-11-02
  • [Remarks] ホームページ等

  • [Remarks] 九州大学・大学院医学研究院・附属心臓血管研究施設・分子細胞情報学部門

    • URL

      http://www.molcar.med.kyushu-u.ac.jp/

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi