Role of osteopontin in airway remodeling and emphysema

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590891
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: KONNO Satoshi Hokkaido University, 病院, 助教 (20399835)
• Co-Investigator(Kenkyū-buntansha): BETSUYAKU Tomoko 北海道大学, 大学院・医学研究科, 准教授 (60333605)
• Project Period (FY): 2008 – 2010
• Keywords: オステオポンチン / 気道リモデリング / 肺気腫

Research Abstract

Using animal models, we evaluated the role of OPN in eosinophilic airway inflammation, allergen sensitization, airway remodeling and emphysema. We have demonstrated that OPN is a novel chamoattractant of eosinophils and is involved in the eosinophilic airway inflammation in asthma. Whereas, OPN inhibited systemic allergen sensitization. The effect of OPN on airway remodeling and emphysema was not observed.

Research Products

• [Journal Article] Role of osteopontn, a multifunctional protein, in allergy and asthma (2011)
  • Author(s): Konno S, Kurokawa M, Uede T, Nishimura M, Huang SK
  • Journal Title: Clin Exp Allergy in press
  • Peer Reviewed
• [Journal Article] Osteopontin is involved in migration of eosinophils in asthma (2009)
  • Author(s): Takahashi A, Kurokawa M, Konno S, Ito K, Kon S, Ashino S, Nishimura T, Uede T, Hizawa N, Huang SK, Nishimura M
  • Journal Title: Clin Exp Allergy 39 Pages: 1152-1159
  • Peer Reviewed
• [Journal Article] Regulatory lolr of DG-derived osteopontin in systemic allergen sensitization (2009)
  • Author(s): Kurokawa M, Konno S, Takahashi S, Plunkett B, Rittling SR, Matsui Y, Kon S, Morimoto J, Uede T, Matsukura S, Kokubu F, Adachi M, Nishimura M, Huang SK
  • Journal Title: Eur J Immunol 39 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Effects of corticosteroids on osteopontin expression in a murine model of allergic asthma (2009)
  • Author(s): Kurokawa M, Konno S, Matsukura S, Kawaguchi M, Ieki K, Suzuki S, Odaka M, Watanabe S, Homma T, Sato M, Takeuchi H, Hirose T, Huang SK, Adachi M
  • Journal Title: Int Arch Allergy Immunol 149 Pages: 7-13
  • Peer Reviewed
• [Presentation] 好酸球性気道炎症におけるオステオポンチンの関与 (2008)
  • Author(s): 高橋歩
  • Organizer: 日本アレルギー学会 秋季学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-29
• [Presentation] Osteopontin is involved in migration of eosinophils in asthma. (2008)
  • Author(s): 高橋歩
  • Organizer: American Thoracic Society annual meeting
  • Place of Presentation: Toronto
  • Year and Date: 2008-05-18
• [Book] 臨床免疫・アレルギー科(オステオポンチンとアレルギー) (2008)
  • Author(s): 黒川正嗣, 今野哲
  • Total Pages: 5
  • Publisher: 科学評論社