2010 Fiscal Year Final Research Report
Elucidation of molecular mechanisms of angiogenesis mediated by angiopoietins and its application for asthma therapy
| Project/Area Number |
20590901
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
KANAZAWA Hiroshi Osaka City University, 大学院・医学研究科, 准教授 (90332957)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 閉塞性肺疾患 |
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| Research Abstract |
Angiopoietin-1 has been shown to protect the adult vasculature against plasma leakage. In contrast, angiopoietin-2, an antagonist of angiopoietin-1, induces loosening of interactions between endothelial and perivascular support cells, and subsequently reduces vascular integrity. Thus, angiopoietin-1 and -2 may play complementary and coordinated roles in airway angiogenesis and microvascular remodeling.
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