Co-analysis of multi-gene polymorphisms related to future development of asthma

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590902
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Osaka City University
• Principal Investigator: YOSHIKAWA Takahiro Osaka City University, 大学院・医学研究科, 准教授 (10381998)
• Project Period (FY): 2008 – 2010
• Keywords: 喘息予備軍 / 多遺伝子同時解析 / 気道過敏性

Research Abstract

Airway hyperresponsiveness (AHR) is a hallmark of bronchial asthma. Some of young atopic adults without respiratory symptoms exhibit AHR, and they as well as those with a remission of childhood asthma constitute a possible risk group for adult-onset asthma. The present study raised the possibility that gene polymorphism of epidermal growth factor receptor (EGFR) and protease activated receptor (PAR)-1 might be associated with the formation of these risk groups.

Research Products

• [Journal Article] Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma. (2011)
  • Author(s): Yoshikawa T, Kanazawa H.
  • Journal Title: Respir Med. 105 Pages: 24-30
  • Peer Reviewed
• [Journal Article] Characteristics of young atopic adults with self-reported past wheeze and airway hyperresponsiveness. (2011)
  • Author(s): Yoshikawa T, Kanazawa H.
  • Journal Title: Allergol Int. (accepted)
  • Peer Reviewed
• [Journal Article] Gene polymorphism of epidermal growth factor receptor and airway hyperresponsiveness in young allergic subjects without respiratory symptoms. (2010)
  • Author(s): Yoshikawa T, Kanazawa H, Tanaka J, Fujimoto S, Yamamoto T.
  • Journal Title: Med Sci Monit 16 Pages: CR163-CR171
  • Peer Reviewed
• [Remarks] ホームページ等
  • URL: http://www.med.osaka-cu.ac.jp/sportsmed/