2010 Fiscal Year Final Research Report
Role of lung fibroblasts on the pathogenesis of COPD
| Project/Area Number |
20590905
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
SUGIURA Hisatoshi Wakayama Medical University, 医学部, 講師 (20445092)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 慢性閉塞性肺疾患 / 線維芽細胞 / 創傷治癒 / アポトーシス / Toll-like受容体 |
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| Research Abstract |
We have proposed the possible pathogenesis of COPD due to loss of tissue repair by lung fibroblasts. The lung fibroblasts from COPD patients had less ability of tissue repair than those from control subjects. In addition, the fibroblasts from COPD patients were sensitive against cigarette smoke extract compared to those from healthy subjects. Toll-like receptor 3 agonist, double-stranded RNA, caused the differentiation of lung fibroblasts into myofibroblasts. These results suggest that lung fibroblasts could be a key cell in the pathogenesis of COPD.
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[Journal Article] High COPD prevalence in the patients with liver diseases.2010
Author(s)
Minakata Y, Ueda H, Akamatsu K, Kanda M, Yanagisawa S, Ichikawa T, Koarai A, Hirano T, Sugiura H, Matsunaga K, Ichinose M
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Journal Title
Intern Med 49
Pages: 2687-2691
Peer Reviewed
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[Journal Article] N-acetyl-L-cysteine inhibits TGF-β_1-induced profibrotic responses in fibroblasts.2009
Author(s)
Sugiura H, Ichikawa T, Liu X, Kobayashi T, Wang XQ, Kawasaki S, Togo S, Kamio K, Mao L, Ann Y, Ichinose M, Rennard SI
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Journal Title
Pulm Pharma Ther 22
Pages: 487-491
Peer Reviewed
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[Journal Article] The possible role of hematopoietic cell kinase in the pathophysiology of chronic obstructive pulmonary disease.2009
Author(s)
Yanagisawa S, Sugiura H, Yokoyama T, Yamagata T, Ichikawa T, Akamatsu K, Koarai A, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
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Journal Title
Peer Reviewed
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[Journal Article] Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects.2009
Author(s)
Yanagisawa S, Koarai A, Sugiura H, Ichikawa T, Kanda M, Tanaka R, Akamatsu K, Hirano T, Matsunaga K, Minakata Y, Ichinose M
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Journal Title
Peer Reviewed
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[Journal Article] The PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1 stimulated fibroblasts.2009
Author(s)
Togo S, Liu X, Wang X, Sugiura H, Kamio K, Kawasaki S, Kobayashi T, Ertl RF, Ahn Y, Holz O, Magnussen H, Fredriksson K, Skold CM, Rennard SI
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Journal Title
Am J Physiol Lung Cell Mol Physiol 296
Pages: L959-L969
Peer Reviewed
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[Journal Article] Peroxynitrite augments fibroblast-mediated tissue remodeling via myofibroblast differentiation.2008
Author(s)
Ichikawa T, Sugiura H, Koarai A, Yanagisawa S, Kanda M, Hayata A, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
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Journal Title
Am J Physiol Lung Cell Mol Physiol 295
Pages: 800-808
Peer Reviewed
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[Journal Article] Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms.2008
Author(s)
Togo S, Holz O, Liu X, Sugiura H, Kamio K, Wang X, Kawasaki S, Ahn Y, Fredriksson K, Skold CM, Mueller KC, Branscheid D, Welker L, Watz H, Magnussen H, Rennard SI
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Journal Title
Am J Respir Crit Care Med. 178
Pages: 248-260
Peer Reviewed
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[Journal Article] Prostacyclin analogs stimulate VEGF production from human lung fibroblasts in culture.2008
Author(s)
Kamio K, Sato T, Liu X, Sugiura H, Togo S, Kobayashi T, Kawasaki S, Wang X, Mao L, Ahn Y, Holz O, Magnussen H, Rennard SI
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Journal Title
Am J Physiol Lung Cell Mol Physiol. 294
Pages: 1226-1232
Peer Reviewed
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[Journal Article] Peak Expiratory Flow Variability Adjusted by Forced Expiratory Volume in One Second is a Good Index for Airway Responsiveness in Asthmatics.2008
Author(s)
Matsunaga K, Kanda M, Hayata A, Yanagisawa S, Ichikawa T, Akamatsu K, Koarai A, Hirano T, Sugiura H, Minakata Y, Ichinose M
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Journal Title
Intern Med 47
Pages: 1107-1112
Peer Reviewed
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[Journal Article] Comparison of bronchodilatory properties of transdermal and inhaled long-acting β_2-agonists.2008
Author(s)
Yamagata T, Hirano T, Sugiura H, Yanagisawa S, Ichikawa T, Ueshima K, Akamatsu K, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
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Journal Title
Pulm Pharmacol Ther 21
Pages: 160-165
Peer Reviewed
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[Presentation] Toll-like receptor 3 (TLR3)の筋線維芽細胞の分化に及ぼす効果2009
Author(s)
杉浦久敏, 市川朋宏, 小荒井晃, 柳澤悟, 南方良章, 松永和人, 平野綱彦, 赤松啓一郎, 田中里江, 神田匡兄, 一ノ瀬正和
Organizer
第59回日本アレルギー学会秋季学術大会
Place of Presentation
秋田
Year and Date
2009-10-29
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[Presentation] Toll-like receptor (TLR3)の線維芽細胞の分化に及ぼす効果2009
Author(s)
杉浦久敏, 市川朋宏, 小荒井晃, 柳澤悟, 南方良章, 松永和人, 平野綱彦, 赤松啓一郎, 田中里江, 神田匡兄, 一ノ瀬正和
Organizer
第49回日本呼吸器学会総会
Place of Presentation
東京
Year and Date
2009-06-13
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[Presentation] 活性窒素種(reactive nitrogen species : RNS)によるMMPの活性化について2008
Author(s)
杉浦久敏, 柳澤悟, 市川朋宏, 小荒井晃, 神田匡兄, 早田敦志, 平野綱彦, 松永和人, 山縣俊之, 南方良章, 一ノ瀬正和
Organizer
第48回日本呼吸器学会学術講演会(ポスター\ミニシンポジウム)
Place of Presentation
神戸
Year and Date
2008-06-17
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[Presentation] Peroxynitrite augments matrix metalloproteinases activity through NF-kB activation.2008
Author(s)
H.Sugiura, S.Yanagisawa, T.Ichikawa, K.Koarai, M.Kanda, A.Hayata, K.Akamatsu, T.Hirano, K.Matsunaga, T.Yamagata, Y.Minakata, M.Ichinose
Organizer
ATS2008 International Conference
Place of Presentation
Toronto, Canada
Year and Date
2008-05-20
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